Takeshi Tsunoda
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Explore the profile of Takeshi Tsunoda including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
148
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Recent Articles
1.
Tsunoda T, Furumura S, Yamazaki H, Maruyama C, Hamano Y, Ogasawara Y, et al.
Commun Chem
. 2025 Jan;
8(1):9.
PMID: 39806036
Lactacystin is an irreversible proteasome inhibitor isolated from Streptomyces lactacystinicus. Despite its importance for its biological activity, the biosynthesis of lactacystin remains unknown. In this study, we identified the lactacystin...
2.
Tanoeyadi S, Zhou W, Osborn A, Tsunoda T, Samadi A, Burade S, et al.
ACS Chem Biol
. 2024 Oct;
19(11):2277-2283.
PMID: 39404639
A cryptic cluster of genes, known as the ebo cluster, has been found in a variety of genomic contexts among bacteria and algae. In NZI7, the ebo cluster (a.k.a. EDB...
3.
Samadi A, Tanoeyadi S, Tsunoda T, Proteau P, Mahmud T
Biochemistry
. 2024 Apr;
63(10):1359-1368.
PMID: 38685871
Sedoheptulose 7-phosphate (SH7P) cyclases are a subset of sugar phosphate cyclases that are known to catalyze the first committed step in many biosynthetic pathways in primary and secondary metabolism. Among...
4.
Umetsu S, Tsunoda T, Kiyanagi H, Inahashi Y, Nonaka K, Dairi T, et al.
J Antibiot (Tokyo)
. 2024 Jan;
77(3):182-184.
PMID: 38200161
Peptidoglycan is an important macromolecule in bacterial cell walls to maintain cell integrity, and its biosynthetic pathway has been well studied. Recently, we demonstrated that some bacteria such as Xanthomonas...
5.
Catalytic Mechanism of Nonglycosidic C-N Bond Formation by the Pseudoglycosyltransferase Enzyme VldE
Tsunoda T, Abuelizz H, Samadi A, Wong C, Awakawa T, Brumsted C, et al.
ACS Catal
. 2023 Dec;
13(20):13369-13382.
PMID: 38130475
The pseudoglycosyltransferase (PsGT) enzyme VldE is a homologue of the retaining glycosyltransferase (GT) trehalose 6-phosphate synthase (OtsA) that catalyzes a coupling reaction between two pseudo-sugar units, GDP-valienol and validamine 7-phosphate,...
6.
Kato H, Sakuta M, Tsunoda T, Nakashima Y, Morita H, Ogasawara Y, et al.
Biomacromolecules
. 2023 Dec;
25(1):349-354.
PMID: 38095677
Poly-γ-glutamic acid (PGA) is a natural polymer of d- and/or l-glutamic acid (Glu) linked by isopeptide bonds. We recently showed that PGA synthetase, an enzyme complex composed of PgsB, PgsC,...
7.
Xiao W, Tsunoda T, Maruyama C, Hamano Y, Ogasawara Y, Dairi T
Biosci Biotechnol Biochem
. 2023 Aug;
87(11):1316-1322.
PMID: 37541960
Grisemycin, salinipeptin, and cypemycin belong to the linaridin class of ribosomally synthesized and posttranslationally modified peptides that contain multiple dehydrobutyrine and D-amino acid residues. The biosynthetic gene clusters of these...
8.
Eida A, Samadi A, Tsunoda T, Mahmud T
Chemistry
. 2023 Apr;
29(33):e202301056.
PMID: 37015882
The potent antitumor antibiotic pactamycin is an aminocyclopentitol-containing natural product produced by the soil bacterium Streptomyces pactum. Recent studies showed that the aminocyclopentitol unit is derived from N-acetyl-D-glucosamine, which is...
9.
Tanoeyadi S, Tsunoda T, Ito T, Philmus B, Mahmud T
ACS Chem Biol
. 2023 Jan;
18(2):367-376.
PMID: 36648321
Acarbose is a well-known microbial specialized metabolite used clinically to treat type 2 diabetes. This natural pseudo-oligosaccharide (PsOS) shows potent inhibitory activity toward various glycosyl hydrolases, including α-glucosidases and α-amylases....
10.
Tsunoda T, Asamizu S, Mahmud T
Biochemistry
. 2022 Oct;
61(22):2628-2635.
PMID: 36288494
Acarbose, a pseudotetrasaccharide produced by several strains of and , is an α-glucosidase inhibitor clinically used to control type II diabetes. Bioinformatic analysis of the biosynthetic gene clusters of acarbose...