Takatsugu Ishimoto
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Explore the profile of Takatsugu Ishimoto including associated specialties, affiliations and a list of published articles.
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Articles
185
Citations
6508
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Recent Articles
1.
Yamazaki M, Ishimoto T
Cancer Sci
. 2025 Jan;
116(3):613-621.
PMID: 39745128
Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment (TME). Given their various roles in tumor progression and treatment resistance, CAFs are promising therapeutic targets in cancer. The elimination...
2.
Kugiyama N, Nagaoka K, Yamada R, Watanabe T, Yamazaki H, Ushijima S, et al.
J Gastroenterol
. 2024 Dec;
PMID: 39661112
Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor prognosis. Mac2-binding protein glycosylated isomer (M2BPGi), a known biomarker for liver fibrosis, is also elevated in other fibrotic...
3.
Semba T, Ishimoto T
Br J Cancer
. 2024 Oct;
131(11):1737-1747.
PMID: 39438630
Tumours are composed of tumour cells and the surrounding tumour microenvironment (TME), and the molecular characterisation of the various elements of the TME and their interactions is essential for elucidating...
4.
Takahashi N, Eltalkhawy Y, Nasu K, Abdelnaser R, Monde K, Habash S, et al.
Biochem Biophys Res Commun
. 2024 Jul;
729:150342.
PMID: 38981402
Despite viral suppression by effective combined antiretroviral therapy, HIV-1-infected individuals have an increased risk of non-AIDS-related overall morbidity, which is due to the persistent chronic inflammation exemplified by the activation...
5.
Zhang J, Fu L, Wang H, Yonemura A, Semba T, Yasuda-Yoshihara N, et al.
Cancer Lett
. 2024 Apr;
591:216901.
PMID: 38641311
Diffuse-type gastric cancer (DGC) is a subtype of gastric cancer that is prone to peritoneal dissemination, with poor patient prognosis. Although intercellular adhesion loss between cancer cells is a major...
6.
Kosumi K, Baba Y, Hara Y, Wang H, Nomoto D, Toihata T, et al.
Ann Surg Oncol
. 2024 Feb;
31(6):3839-3849.
PMID: 38421531
Background: Obesity is associated with increased mortality in various cancers, but the relationship between obesity and clinical outcomes in unresectable or recurrent esophageal cancer who receive immune checkpoint inhibitors (ICIs)...
7.
Yonemura A, Semba T, Zhang J, Fan Y, Yasuda-Yoshihara N, Wang H, et al.
Cell Rep
. 2024 Jan;
43(1):113613.
PMID: 38232734
Malignant ascites accompanied by peritoneal dissemination contain various factors and cell populations as well as cancer cells; however, how the tumor microenvironment is shaped in ascites remains unclear. Single-cell proteomic...
8.
Baba Y, Yasuda N, Bundo M, Nakachi Y, Ueda J, Ishimoto T, et al.
Cancer Sci
. 2023 Nov;
115(1):247-256.
PMID: 38013627
The long interspersed nuclear element-1 (LINE-1) retrotransposons are a major family of mobile genetic elements, comprising approximately 17% of the human genome. The methylation state of LINE-1 is often used...
9.
Hu X, Yasuda T, Yasuda-Yosihara N, Yonemura A, Umemoto T, Nakachi Y, et al.
JHEP Rep
. 2023 Nov;
5(12):100892.
PMID: 37942226
Background & Aims: Hepatocellular carcinoma (HCC) mainly develops from chronic hepatitis. Metabolic dysfunction-associated steatohepatitis (MASH) has gradually become the main pathogenic factor for HCC given the rising incidence of obesity...
10.
Kitamura F, Semba T, Yasuda-Yoshihara N, Yamada K, Nishimura A, Yamasaki J, et al.
JCI Insight
. 2023 Sep;
8(20.
PMID: 37733442
Glycolysis is highly enhanced in pancreatic ductal adenocarcinoma (PDAC) cells; thus, glucose restrictions are imposed on nontumor cells in the PDAC tumor microenvironment (TME). However, little is known about how...