Takashi Yamoto
Overview
Explore the profile of Takashi Yamoto including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
34
Citations
224
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Fujimoto K, Kishino H, Hashimoto K, Watanabe K, Yamoto T, Mori K
J Toxicol Sci
. 2020 Jun;
45(6):339-347.
PMID: 32493876
The metabolomic profiles of rat primary hepatocytes following treatment with rotenone, FCCP, or (+)-usnic acid were determined using liquid chromatography-mass spectrometry/mass spectrometry and gas chromatography-mass spectrometry. Significant and similar changes...
2.
Kishino Y, Hasegawa T, Yamoto T, Mori K
J Toxicol Sci
. 2019 Oct;
44(10):701-709.
PMID: 31588061
Genotoxicity and carcinogenicity profiles of drugs occasionally vary across species due to species difference in drug metabolic profile. To clarify the effect of species differences in the metabolic profile on...
3.
Kishino Y, Hasegawa T, Arakawa S, Shibaya Y, Yamoto T, Mori K
J Toxicol Sci
. 2019 Mar;
44(3):145-153.
PMID: 30842367
A high incidence of positive results is obtained with in vitro genotoxicity tests, which do not correlate with the in vivo negative results in many cases. To address this issue,...
4.
Kishino Y, Hasegawa T, Kato A, Nishiya Y, Rozhnal V, Watanabe K, et al.
Mutat Res Genet Toxicol Environ Mutagen
. 2019 Jan;
838:37-45.
PMID: 30678826
We investigated the relationship between metabolic activities of cytochrome P450 (CYP) isozymes present in microsomal fractions derived from the livers of 78 donors and micronucleus induction by cyclophosphamide (CPA). Consequently,...
5.
Obayashi H, Kobayashi N, Nezu Y, Yamoto T, Shirai M, Asai F
J Toxicol Sci
. 2018 Oct;
43(10):601-610.
PMID: 30298848
Previously, we have demonstrated the potential of plasma 2-hydroxyglutarate (2HG) as an easily detectable biomarker for skeletal muscle injury in rats. Here, we examined whether plasma 2HG was superior to...
6.
Obayashi H, Kobayashi N, Nezu Y, Yamoto T, Shirai M, Asai F
J Toxicol Sci
. 2017 Jul;
42(4):385-396.
PMID: 28717097
To identify new candidate biomarkers for skeletal muscle toxicity, an unbiased metabolomic analysis was performed in rats treated with two distinct myotoxicants, cerivastatin (CER) and tetramethyl-p-phenylenediamine (TMPD). Skeletal muscle toxicity...
7.
Kiyosawa N, Ando Y, Manabe S, Yamoto T
J Toxicol Pathol
. 2012 Jan;
22(1):35-52.
PMID: 22271975
Toxicogenomics (TGx) is a widely used technique in the preclinical stage of drug development to investigate the molecular mechanisms of toxicity. A number of candidate TGx biomarkers have now been...
8.
Fukuhara K, Ohno A, Ando Y, Yamoto T, Okuda H
Drug Metab Pharmacokinet
. 2011 Jun;
26(4):399-406.
PMID: 21670543
The widely used analgesic-antipyretic drug acetaminophen (APAP) is known to cause serious liver necrosis at high doses in man and experimental animals. For studies of toxic processes, 1H NMR spectroscopy...
9.
Yamauchi S, Kiyosawa N, Ando Y, Watanabe K, Niino N, Ito K, et al.
Arch Toxicol
. 2010 Dec;
85(9):1045-56.
PMID: 21161181
Hepatic transcriptome and proteome responses against glutathione depletion were investigated by Affymetrix GeneChip Microarray and 2-dimensional gel electrophoresis (2D-DIGE), followed by MALDI-TOF-MS analysis and utilizing a glutathione-depleted rat model treated...
10.
Igarashi M, Nagata M, Itoh S, Yamoto T, Tsuda S
J Toxicol Sci
. 2010 Dec;
35(6):881-9.
PMID: 21139338
To determine the optimum timing of partial hepatectomy (PH) in a previously developed mouse liver micronucleus test (Igarashi and Shimada, 1997), the relation between DNA damage and micronucleus was examined...