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Takashi Tsunematsu

Explore the profile of Takashi Tsunematsu including associated specialties, affiliations and a list of published articles. Areas
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Articles 14
Citations 227
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Recent Articles
1.
Toda S, Yamamoto Y, Ookubo Y, Hayashi H, Tsunematsu T, Kadoya M, et al.
Gland Surg . 2023 Nov; 12(10):1441-1448. PMID: 38021198
Background: Cardiac metastasis from thyroid cancer is rare and has an extremely poor prognosis. Although some patients who undergo heart surgery survive, the therapeutic effectiveness of systemic therapy is limited....
2.
Kikuchi S, Tsukahara K, Sakamaki K, Morita Y, Takamura T, Fukui K, et al.
Heart Vessels . 2019 Jan; 34(6):1002-1013. PMID: 30599063
Some experimental studies have shown that direct oral anticoagulants (DOACs) have anti-inflammatory effects. However, the interval changes in inflammatory markers in patients with non-valvular atrial fibrillation (AF) who receive DOACs...
3.
Suzuki H, Tsunematsu T, Takahashi H, Yasuda S, Gyotoku D, Miyajima K, et al.
J Cardiol Cases . 2018 Oct; 15(5):145-149. PMID: 30279763
Heparin-induced thrombocytopenia (HIT) is an adverse immune-mediated drug reaction that is associated with thromboembolic complications. We report the case of an 82-year-old man with unstable angina pectoris who suffered from...
4.
Tsunematsu T, Okumura S, Mototani Y, Ohnuki Y, Jin H, Cai W, et al.
Biochem Biophys Res Commun . 2015 Feb; 458(3):531-535. PMID: 25677623
Myocardial β-adrenergic receptor (β-AR) β1- and β2-subtypes are highly homologous, but play opposite roles in cardiac apoptosis and heart failure, as do cardiac adenylyl cyclase (AC) subtypes 5 (AC5) and...
5.
Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, et al.
J Clin Invest . 2014 Jun; 124(6):2785-801. PMID: 24892712
PKA phosphorylates multiple molecules involved in calcium (Ca2+) handling in cardiac myocytes and is considered to be the predominant regulator of β-adrenergic receptor-mediated enhancement of cardiac contractility; however, recent identification...
6.
Bai Y, Tsunematsu T, Jiao Q, Ohnuki Y, Mototani Y, Shiozawa K, et al.
J Pharmacol Sci . 2012 Aug; 119(4):381-9. PMID: 22850613
We previously demonstrated that type 5 adenylyl cyclase (AC5) functions in autonomic regulation in the heart. Based on that work, we hypothesized that pharmacological modulation of AC5 activity could regulate...
7.
Okumura S, Tsunematsu T, Bai Y, Jiao Q, Ono S, Suzuki S, et al.
J Appl Physiol (1985) . 2008 May; 105(1):173-9. PMID: 18450980
It is well known that autonomic nervous activity is altered under microgravity, leading to disturbed regulation of cardiac function, such as heart rate. Autonomic regulation of the heart is mostly...
8.
Iwatsubo K, Suzuki S, Li C, Tsunematsu T, Nakamura F, Okumura S, et al.
Am J Physiol Cell Physiol . 2007 Sep; 293(5):C1498-508. PMID: 17804610
Dopamine signaling plays a major role in regulation of neuronal apoptosis. During the postnatal period, dopamine signaling is known to be dramatically changed in the striatum. However, because it is...
9.
Nishizawa T, Iwase M, Kanazawa H, Ichihara S, Ichihara G, Nagata K, et al.
Circ J . 2004 Oct; 68(11):1051-60. PMID: 15502388
Background: The relationship between enhanced myocardial oxidative stress and impaired beta-adrenergic signaling remains to be characterized during the development of dilated cardiomyopathy. Methods And Results: Alterations in myocardial oxidative stress...
10.
Oshikawa J, Otsu K, Toya Y, Tsunematsu T, Hankins R, Kawabe J, et al.
Proc Natl Acad Sci U S A . 2004 Aug; 101(34):12670-5. PMID: 15314230
Type 2 diabetes is preceded by the development of insulin resistance, in which the action of insulin is impaired, largely in skeletal muscles. Caveolin-3 (Cav3) is a muscle-specific subtype of...