Takashi Moriguchi
Overview
Explore the profile of Takashi Moriguchi including associated specialties, affiliations and a list of published articles.
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Articles
63
Citations
2827
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Recent Articles
1.
Shirota Y, Ohmori S, Engel J, Moriguchi T
PLoS One
. 2024 Dec;
19(12):e0315446.
PMID: 39739870
The vascular endothelium is vital for cardio-pulmonary homeostasis and, thus, plays a crucial role in preventing life-threatening lung diseases. The transcription factor GATA2 is essential for hematopoiesis and maintaining vascular...
2.
Hayashi M, Ohmori S, Kawai Y, Moriguchi T
Exp Anim
. 2024 Sep;
74(1):104-113.
PMID: 39231733
Sepsis-induced acute lung injury represents a significant threat to human health and is frequently associated with pulmonary thrombosis due to dysregulation of the coagulofibrinolytic system. Plasmin, the major protease that...
3.
Uemura S, Mochizuki T, Kato Y, Mioka T, Watanabe R, Fuchita M, et al.
J Biochem
. 2024 Apr;
176(2):155-166.
PMID: 38621657
Hydrostatic pressure is a common mechanical stressor that modulates metabolism and reduces cell viability. Eukaryotic cells have genetic programs to cope with hydrostatic pressure stress and maintain intracellular homeostasis. However,...
4.
Watanabe-Asaka T, Hayashi M, Harada T, Uemura S, Takai J, Nakamura Y, et al.
J Biochem
. 2024 Jan;
175(5):551-560.
PMID: 38168819
Lymphedema has become a global health issue following the growing number of cancer surgeries. Curative or supportive therapeutics have long been awaited for this refractory condition. Transcription factor GATA2 is...
5.
Xu X, Fukuda T, Takai J, Morii S, Sun Y, Liu J, et al.
J Biol Chem
. 2023 Dec;
300(1):105513.
PMID: 38042483
α1,6-Fucosyltransferase (Fut8) catalyzes the transfer of fucose to the innermost GlcNAc residue of N-glycan to form core fucosylation. Our previous studies showed that lipopolysaccharide (LPS) treatment highly induced neuroinflammation in...
6.
Ohmori S, Takai J, Uemura S, Otsuki A, Mori T, Ohneda K, et al.
iScience
. 2022 Sep;
25(9):104942.
PMID: 36072552
Mast cells serve as a first-line defense of innate immunity. Interleukin-6 (IL-6) induced by bacterial lipopolysaccharide (LPS) in mast cells plays a crucial role in antibacterial protection. The zinc finger...
7.
Uemura S, Moriguchi T
Glycobiology
. 2022 Jun;
32(9):778-790.
PMID: 35713525
Mannosyl phosphorylceramide (MIPC) is a membrane lipid classified as a complex sphingolipid in Saccharomyces cerevisiae. MIPC is synthesized by 2 redundant enzymes, Sur1/Csg1 and Csh1, in the Golgi lumen. MIPC...
8.
Satoh H, Arai Y, Furukawa E, Moriguchi T, Hama N, Urushidate T, et al.
Carcinogenesis
. 2022 May;
43(7):613-623.
PMID: 35561328
The transcription factor Nrf2 plays a crucial role in the anti-oxidative stress response, protection of DNA from injury and DNA repair mechanisms. Nrf2 activity reduces cancer initiation, but how Nrf2...
9.
Takai J, Shimada T, Nakamura T, Engel J, Moriguchi T
iScience
. 2021 Sep;
24(8):102836.
PMID: 34471858
Infectious diseases continually pose global medical challenges. The transcription factor GATA2 establishes gene networks and defines cellular identity in hematopoietic stem/progenitor cells and in progeny committed to specific lineages. GATA2-haploinsufficient...
10.
Yu L, Myers G, Ku C, Schneider E, Wang Y, Singh S, et al.
Blood
. 2021 Jul;
138(18):1691-1704.
PMID: 34324630
Histone H3 lysine 4 methylation (H3K4Me) is most often associated with chromatin activation, and removing H3K4 methyl groups has been shown to be coincident with gene repression. H3K4Me demethylase KDM1a/LSD1...