James Douglas Engel
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Explore the profile of James Douglas Engel including associated specialties, affiliations and a list of published articles.
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118
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4425
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Recent Articles
1.
Shirota Y, Ohmori S, Engel J, Moriguchi T
PLoS One
. 2024 Dec;
19(12):e0315446.
PMID: 39739870
The vascular endothelium is vital for cardio-pulmonary homeostasis and, thus, plays a crucial role in preventing life-threatening lung diseases. The transcription factor GATA2 is essential for hematopoiesis and maintaining vascular...
2.
Wang Y, Myers G, Yu L, Deng K, Balbin-Cuesta G, Singh S, et al.
Blood
. 2024 Oct;
144(26):2762-2772.
PMID: 39393056
Nuclear receptor TR4 (NR2C2) was previously shown to bind to the -117 position of the γ-globin gene promoters in vitro, which overlaps the more recently described BCL11 transcription factor A...
3.
Ishihara D, Hasegawa A, Hirano I, Engel J, Yamamoto M, Shimizu R
Exp Hematol Oncol
. 2024 Feb;
13(1):24.
PMID: 38409186
Transcription factor GATA1 controls the delicate balance between proliferation, differentiation and apoptosis in both the erythroid and megakaryocytic lineages. In addition to full-length GATA1, there is an GATA1 isoform, GATA1s,...
4.
Hirano I, Abe K, Engel J, Yamamoto M, Shimizu R
Exp Hematol Oncol
. 2024 Feb;
13(1):23.
PMID: 38409047
GATA1 plays a critical role in differentiation, proliferation, and apoptosis during erythropoiesis. We developed a Gata1 knock-down allele (Gata1.05) that results in GATA1 expression at 5% of endogenous level. In...
5.
Myers G, Wang Y, Wang Q, Friedman A, Sanchez-Martinez A, Liu X, et al.
Blood Adv
. 2023 Aug;
7(19):5727-5732.
PMID: 37552129
Our current understanding of the kinetics and dynamics of erythroid differentiation is based almost entirely on the ex vivo expansion of cultured hematopoietic progenitor cells. In this study, we used...
6.
Wang B, Wang C, Wan Y, Gao J, Ma Y, Zhang Y, et al.
Cell Discov
. 2022 May;
8(1):41.
PMID: 35534476
Ribosomal protein dysfunction causes diverse human diseases, including Diamond-Blackfan anemia (DBA). Despite the universal need for ribosomes in all cell types, the mechanisms underlying ribosomopathies, which are characterized by tissue-specific...
7.
Yu L, Myers G, Schneider E, Wang Y, Mathews R, Lim K, et al.
Blood Adv
. 2022 Mar;
6(11):3280-3285.
PMID: 35240686
Human γ-globin is predominantly expressed in fetal liver erythroid cells during gestation from 2 nearly identical genes, HBG1 and HBG2, that are both perinatally silenced. Reactivation of these fetal genes...
8.
King R, Lin Z, Balbin-Cuesta G, Myers G, Friedman A, Zhu G, et al.
Sci Adv
. 2021 Nov;
7(48):eabj5293.
PMID: 34818036
Congenital dyserythropoietic anemia type II (CDAII) results from loss-of-function mutations in . In contrast to humans, SEC23B-deficient mice deletion do not exhibit CDAII but die perinatally with pancreatic degeneration. Here,...
9.
Takai J, Shimada T, Nakamura T, Engel J, Moriguchi T
iScience
. 2021 Sep;
24(8):102836.
PMID: 34471858
Infectious diseases continually pose global medical challenges. The transcription factor GATA2 establishes gene networks and defines cellular identity in hematopoietic stem/progenitor cells and in progeny committed to specific lineages. GATA2-haploinsufficient...
10.
Yu L, Lemay P, Ludlow A, Guyot M, Jones M, Mohamed F, et al.
Blood Adv
. 2021 Aug;
5(20):4167-4178.
PMID: 34464976
Ribosome dysfunction is implicated in multiple abnormal developmental and disease states in humans. Heterozygous germline mutations in genes encoding ribosomal proteins are found in most individuals with Diamond-Blackfan anemia (DBA),...