Takashi Furusawa
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Explore the profile of Takashi Furusawa including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
928
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Recent Articles
1.
Li H, Furusawa T, Cavero R, Xiao Y, Chari R, Wu X, et al.
Redox Biol
. 2025 Jan;
80:103503.
PMID: 39854937
Metabolic pathways fuel tumor progression and resistance to stress conditions including chemotherapeutic drugs, such as DNA damage response (DDR) inhibitors. Yet, significant gaps persist in how metabolic pathways confer resistance...
2.
Furusawa T, Cavero R, Liu Y, Li H, Xu X, Andresson T, et al.
Mol Carcinog
. 2024 Feb;
63(6):1024-1037.
PMID: 38411275
Homologous recombination (HR) and poly ADP-ribosylation are partially redundant pathways for the repair of DNA damage in normal and cancer cells. In cell lines that are deficient in HR, inhibition...
3.
Nanduri R, Furusawa T, Lobanov A, He B, Xie C, Dadkhah K, et al.
Nat Commun
. 2022 Nov;
13(1):7303.
PMID: 36435799
White adipose tissue browning is a key metabolic process controlled by epigenetic factors that facilitate changes in gene expression leading to altered cell identity. We find that male mice lacking...
4.
He B, Zhu I, Postnikov Y, Furusawa T, Jenkins L, Nanduri R, et al.
Epigenetics Chromatin
. 2022 Jun;
15(1):23.
PMID: 35761366
Background: Nucleosomal binding proteins, HMGN, is a family of chromatin architectural proteins that are expressed in all vertebrate nuclei. Although previous studies have discovered that HMGN proteins have important roles...
5.
Zhang S, Postnikov Y, Lobanov A, Furusawa T, Deng T, Bustin M
Commun Biol
. 2022 Feb;
5(1):159.
PMID: 35197580
Nucleosomes containing acetylated H3K27 are a major epigenetic mark of active chromatin and identify cell-type specific chromatin regulatory regions which serve as binding sites for transcription factors. Here we show...
6.
Cabal-Hierro L, van Galen P, Prado M, Higby K, Togami K, Mowery C, et al.
Nat Commun
. 2020 Mar;
11(1):1406.
PMID: 32179749
Chromatin organization is a highly orchestrated process that influences gene expression, in part by modulating access of regulatory factors to DNA and nucleosomes. Here, we report that the chromatin accessibility...
7.
Nanduri R, Furusawa T, Bustin M
Int J Mol Sci
. 2020 Jan;
21(2).
PMID: 31936777
Chromatin plays a key role in regulating gene expression programs necessary for the orderly progress of development and for preventing changes in cell identity that can lead to disease. The...
8.
Zhang S, Deng T, Tang W, He B, Furusawa T, Ambs S, et al.
Nucleic Acids Res
. 2019 Mar;
47(9):4449-4461.
PMID: 30838422
HMGN proteins localize to chromatin regulatory sites and modulate the cell-type specific transcription profile; however, the molecular mechanism whereby these ubiquitous nucleosome binding proteins affect gene expression is not fully...
9.
He B, Deng T, Zhu I, Furusawa T, Zhang S, Tang W, et al.
Nat Commun
. 2018 Dec;
9(1):5240.
PMID: 30532006
The dynamic nature of the chromatin epigenetic landscape plays a key role in the establishment and maintenance of cell identity, yet the factors that affect the dynamics of the epigenome...
10.
Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression
Mowery C, Reyes J, Cabal-Hierro L, Higby K, Karlin K, Wang J, et al.
Cell Rep
. 2018 Nov;
25(7):1898-1911.e5.
PMID: 30428356
Down syndrome (DS, trisomy 21) is associated with developmental abnormalities and increased leukemia risk. To reconcile chromatin alterations with transcriptome changes, we performed paired exogenous spike-in normalized RNA and chromatin...