Takako Usami
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Explore the profile of Takako Usami including associated specialties, affiliations and a list of published articles.
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11
Citations
1017
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Recent Articles
1.
Nagaishi T, Watabe T, Kotake K, Kumazawa T, Aida T, Tanaka K, et al.
Gut
. 2021 May;
71(3):487-496.
PMID: 33963042
Objective: Although immunoglobulin A (IgA) is abundantly expressed in the gut and known to be an important component of mucosal barriers against luminal pathogens, its precise function remains unclear. Therefore,...
2.
Yamada T, Takechi M, Yokoyama N, Hiraoka Y, Ishikubo H, Usami T, et al.
Dev Dyn
. 2020 Jan;
249(5):622-635.
PMID: 31900962
Background: Splicing factor 3B subunit 4 (SF3B4) is a causative gene of an acrofacial dysostosis, Nager syndrome. Although in vitro analyses of SF3B4 have proposed multiple noncanonical functions unrelated to...
3.
Adachi T, Kakuta S, Aihara Y, Kamiya T, Watanabe Y, Osakabe N, et al.
Front Immunol
. 2016 Dec;
7:601.
PMID: 28018362
Probiotics, such as lactic acid bacteria (LAB) and var. , have been shown to modulate immune responses. It is important to understand how probiotic bacteria impact intestinal epithelial cells (IECs),...
4.
Aida T, Nakade S, Sakuma T, Izu Y, Oishi A, Mochida K, et al.
BMC Genomics
. 2016 Nov;
17(1):979.
PMID: 27894274
Background: Although CRISPR/Cas enables one-step gene cassette knock-in, assembling targeting vectors containing long homology arms is a laborious process for high-throughput knock-in. We recently developed the CRISPR/Cas-based precise integration into...
5.
Yoshikawa S, Usami T, Kikuta J, Ishii M, Sasano T, Sugiyama K, et al.
Sci Rep
. 2016 Jan;
6:18738.
PMID: 26732477
Calcium ion (Ca(2+)) signaling is a typical phenomenon mediated through immune receptors, such as the B-cell antigen receptor (BCR), and it is important for their biological activities. To analyze the...
6.
Ono R, Ishii M, Fujihara Y, Kitazawa M, Usami T, Kaneko-Ishino T, et al.
Sci Rep
. 2015 Jul;
5:12281.
PMID: 26216318
The CRISPR/Cas system efficiently introduces double strand breaks (DSBs) at a genomic locus specified by a single guide RNA (sgRNA). The DSBs are subsequently repaired through non-homologous end joining (NHEJ)...
7.
Aida T, Chiyo K, Usami T, Ishikubo H, Imahashi R, Wada Y, et al.
Genome Biol
. 2015 May;
16:87.
PMID: 25924609
Although the CRISPR/Cas system has enabled one-step generation of knockout mice, low success rates of cassette knock-in limit its application range. Here we show that cloning-free, direct nuclear delivery of...
8.
Neely G, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, et al.
Cell
. 2010 Apr;
141(1):142-53.
PMID: 20371351
Heart diseases are the most common causes of morbidity and death in humans. Using cardiac-specific RNAi-silencing in Drosophila, we knocked down 7061 evolutionarily conserved genes under conditions of stress. We...
9.
Suganami T, Yuan X, Shimoda Y, Uchio-Yamada K, Nakagawa N, Shirakawa I, et al.
Circ Res
. 2009 May;
105(1):25-32.
PMID: 19478204
Obese adipose tissue is markedly infiltrated by macrophages, suggesting that they may participate in the inflammatory pathways that are activated in obese adipose tissue. Evidence has suggested that saturated fatty...
10.
Ono R, Nakamura K, Inoue K, Naruse M, Usami T, Wakisaka-Saito N, et al.
Nat Genet
. 2005 Dec;
38(1):101-6.
PMID: 16341224
By comparing mammalian genomes, we and others have identified actively transcribed Ty3/gypsy retrotransposon-derived genes with highly conserved DNA sequences and insertion sites. To elucidate the functions of evolutionarily conserved retrotransposon-derived...