Takakazu Mitani
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Explore the profile of Takakazu Mitani including associated specialties, affiliations and a list of published articles.
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34
Citations
348
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Recent Articles
1.
Mitani T
Biosci Biotechnol Biochem
. 2025 Jan;
PMID: 39805718
Food-derived polyphenols and some alkaloids have reported bioactivities related the prevention of systemic metabolic disorders such as obesity, glucose intolerance, and dyslipidemia. For food-derived components to exert their functions in...
2.
Yonemoto E, Ihara R, Tanaka E, Mitani T
Biosci Biotechnol Biochem
. 2024 Jul;
88(10):1188-1198.
PMID: 39025807
Cocoa extract (CE) offers several health benefits, such as antiobesity and improved glucose intolerance. However, the mechanisms remain unclear. Adipose tissue includes white adipose tissue (WAT) and brown adipose tissue....
3.
Hamada R, Yonezawa A, Matsumoto K, Mitani T, Takagi T, Muto A, et al.
Am J Physiol Gastrointest Liver Physiol
. 2024 Jul;
327(3):G414-G423.
PMID: 38981617
Immunoglobulin A (IgA)-mediated mucosal immunity is important for the host because it contributes to reducing infection risk and to establishing host-microbe symbiosis. BTB and CNC homology 1 (Bach1) is a...
4.
Watanabe S, Haruyama R, Umezawa K, Tomioka I, Nakamura S, Katayama S, et al.
J Nutr Biochem
. 2023 Aug;
121:109433.
PMID: 37648097
A decrease in the NAD level in adipocytes causes adipose-tissue dysfunction, leading to systemic glucose, and lipid metabolism failure. Therefore, it is necessary to develop small molecules and nutraceuticals that...
5.
Yamamoto M, Miyoshi M, Morioka K, Mitani T, Takaya T
Biochem Biophys Res Commun
. 2023 May;
664:1-8.
PMID: 37127012
A myogenetic oligodeoxynucleotide, iSN04, is the 18-base single-stranded DNA that acts as an anti-nucleolin aptamer. iSN04 has been reported to restore myogenic differentiation by suppressing inflammatory responses in myoblasts isolated...
6.
Nakashima M, Mitani T
J Nutr Sci Vitaminol (Tokyo)
. 2022 Oct;
68(5):420-428.
PMID: 36310076
Vitamin D and its receptor (vitamin D receptor; VDR) regulate calcium homeostasis in mammals. Recently, studies have shown that serum concentrations of 25-hydroxyvitamin D (25VD) are negatively associated with insulin...
7.
Ikeda T, Watanabe S, Mitani T
Biosci Biotechnol Biochem
. 2021 Dec;
86(2):260-272.
PMID: 34849563
Genistein exerts antiadipogenic effects, but its target molecules remain unclear. Here, we delineated the molecular mechanism underlying the antiadipogenic effect of genistein. A pulldown assay using genistein-immobilized beads identified adenine...
8.
Tanaka E, Mitani T, Nakashima M, Yonemoto E, Fujii H, Ashida H
J Nutr Biochem
. 2021 Nov;
100:108898.
PMID: 34748921
The adipocytes play an important role in driving the obese-state-white adipose tissue (WAT) stores the excess energy as fat, wherein brown adipose tissue (BAT) is responsible for energy expenditure via...
9.
Yoshioka Y, Kitakaze T, Mitani T, Furuyashiki T, Ashida H
J Clin Biochem Nutr
. 2020 Aug;
67(1):36-42.
PMID: 32801467
Enzymatically synthesized glycogen is a product from starch. Enzymatically synthesized glycogen has been reported to possess various health beneficial effects such as anti-oxidative and anti-inflammatory effects. In this study, we...
10.
Mitani T, Watanabe S, Wada K, Fujii H, Nakamura S, Katayama S
Biochem Biophys Res Commun
. 2019 Dec;
522(3):770-775.
PMID: 31791580
A decline in intracellular nicotinamide adenine mononucleotide (NAD) causes adipose tissue dysfunction. Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step in the NAD biosynthesis pathway. However, the molecular mechanism that mediates...