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» Authors » Takahito Nishiyama

Takahito Nishiyama

Explore the profile of Takahito Nishiyama including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 23
Citations 256
Followers 0
Related Specialties
Biochemistry
Pharmacology
Toxicology
Top 10 Co-Authors
Akira Hiratsuka
Kenichiro Ogura
Tomokazu Ohnuma
Tadashi Watabe
Kei Muro
Teppei Kaku
Tadashi Izawa
Hiroaki Nakano
Nahoko Hayashi
Shigetoshi Kadota
Published In
Arch Biochem Biophys
J Toxicol Sci
Biochem Pharmacol
Biochem Biophys Res Commun
Drug Metab Pharmacokinet
Affiliations
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Recent Articles
1.
Magnolol protects PC12 cells from hydrogen peroxide or 6-hydroxydopamine induced cytotoxicity
Nishiyama T, Masuda Y, Izawa T, Ohnuma T, Ogura K, Hiratsuka A
J Toxicol Sci . 2019 Nov; 44(11):753-758. PMID: 31708532
Magnoliae Cortex contains a range of bioactive components including terpenes (e.g. α-, β- and γ-eudesmol), phenylpropanoids (e.g. honokiol and magnolol) and alkaloids (e.g. magnocurarine). We recently reported that pretreatment of...
2.
4-(Hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronide has the potential to form 2'-deoxyguanosine and N-acetylcysteine adducts
Nishiyama T, Hayashi N, Yanagita H, Ohnuma T, Ogura K, Hiratsuka A
J Toxicol Sci . 2019 Oct; 44(10):693-699. PMID: 31588060
Cigarette smoking is a risk factor for the development of various cancers, such as lung, nasal, liver and bladder cancers. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific nitrosamine, is implicated in human lung...
3.
Procyanidins from Cinnamomi Cortex promote proteasome-independent degradation of nuclear Nrf2 through phosphorylation of insulin-like growth factor-1 receptor in A549 cells
Ohnuma T, Sakamoto K, Shinoda A, Takagi C, Ohno S, Nishiyama T, et al.
Arch Biochem Biophys . 2017 Oct; 635:66-73. PMID: 29051069
Many lines of evidence demonstrate that transcription factor nuclear factor-E2-related factor 2 (Nrf2) plays essential roles in cancer cell proliferation and resistance to chemotherapy, thereby indicating that suppression of abnormal...
4.
Selective antagonization of activated Nrf2 and inhibition of cancer cell proliferation by procyanidins from Cinnamomi Cortex extract
Ohnuma T, Anzai E, Suzuki Y, Shimoda M, Saito S, Nishiyama T, et al.
Arch Biochem Biophys . 2015 Sep; 585:17-24. PMID: 26365032
Nuclear factor-E2-related factor 2 (Nrf2) is an important transcription factor and plays a central role in inducible expression of many cytoprotective genes. Recent studies have reported that various cancer cells...
5.
Formation and stability of 4-(hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronide, a stable form of reactive intermediate produced from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, in mice
Nishiyama T, Hayashi N, Kakurai N, Yanagita H, Kuriyama A, Miyamoto C, et al.
J Toxicol Sci . 2014 Jul; 39(4):515-21. PMID: 25056776
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific nitrosamine, induced lung tumors in rodents and is likely involved in human lung cancer. 4-(Hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (HO-methyl NNK) glucuronide, a glucuronide of the reactive intermediate of NNK,...
6.
Tissue distributions of 4-(hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronide, a stable form of reactive intermediate produced from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, in the rat
Nishiyama T, Ogura K, Ohnuma T, Hiratsuka A
J Toxicol Sci . 2014 Mar; 39(2):263-7. PMID: 24646707
The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), induces lung tumors in rodents and has been suggested as a causative factor in human lung cancer. NNK is activated by α-hydroxylation at either the...
7.
Enhanced sensitivity of A549 cells to the cytotoxic action of anticancer drugs via suppression of Nrf2 by procyanidins from Cinnamomi Cortex extract
Ohnuma T, Matsumoto T, Itoi A, Kawana A, Nishiyama T, Ogura K, et al.
Biochem Biophys Res Commun . 2011 Sep; 413(4):623-9. PMID: 21925486
Nuclear factor-E2-related factor 2 (Nrf2) is an important cytoprotective transcription factor because Nrf2-regulated enzymes play a key role in antioxidant and detoxification processes. Recent studies have reported that lung cancer...
8.
Involvement of different human glutathione transferase isoforms in the glutathione conjugation of reactive metabolites of troglitazone
Okada R, Maeda K, Nishiyama T, Aoyama S, Tozuka Z, Hiratsuka A, et al.
Drug Metab Dispos . 2011 Sep; 39(12):2290-7. PMID: 21914835
Null mutation of glutathione transferase (GST) M1 and GSTT1 was reported to correlate statistically with an abnormal increase in the plasma levels of alanine aminotransferase or aspartate aminotransferase caused by...
9.
Dietary diacetylene falcarindiol induces phase 2 drug-metabolizing enzymes and blocks carbon tetrachloride-induced hepatotoxicity in mice through suppression of lipid peroxidation
Ohnuma T, Anan E, Hoashi R, Takeda Y, Nishiyama T, Ogura K, et al.
Biol Pharm Bull . 2011 Mar; 34(3):371-8. PMID: 21372387
Falcarindiol is a diacetylenic natural product containing unique carbon-carbon triple bonds. Mice were orally administrated falcarindiol (100 mg/kg), and drug-metabolizing and antioxidant enzymes were monitored in several tissues of mice....
10.
Cooperation of NAD(P)H:quinone oxidoreductase 1 and UDP-glucuronosyltransferases reduces menadione cytotoxicity in HEK293 cells
Nishiyama T, Izawa T, Usami M, Ohnuma T, Ogura K, Hiratsuka A
Biochem Biophys Res Commun . 2009 Dec; 394(3):459-63. PMID: 20035715
Previous studies have shown that NAD(P)H:quinone oxidoreductase 1 (NQO1) plays an important role in the detoxification of menadione (2-methyl-1,4-naphthoquinone, also known as vitamin K3). However, menadiol (2-methyl-1,4-naphthalenediol) formed from menadione...