Tadashi Hashimoto
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Explore the profile of Tadashi Hashimoto including associated specialties, affiliations and a list of published articles.
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35
Citations
473
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Recent Articles
11.
Miyagi Y, Tada K, Takayoshi R, Oguni N, Sato Y, Shibata M, et al.
Acta Med Okayama
. 2018 Apr;
72(2):115-119.
PMID: 29674759
We devised biomathematics-based formulae to estimate the standard values of fetal growth of Japanese after 22 weeks' gestation. The growth rates of bi-parietal diameter (BPD), abdominal circumference (AC), femur length...
12.
Ozawa H, Imaizumi A, Sumi Y, Hashimoto T, Kanai M, Makino Y, et al.
Biol Pharm Bull
. 2017 Sep;
40(9):1515-1524.
PMID: 28867734
Curcumin, a polyphenol derived from the rhizome of the naturally occurring plant Curcuma longa, has various pharmacological actions such as antioxidant and anti-inflammatory effects. In this paper, we evaluated the...
13.
Ishikawa C, Senba M, Hashimoto T, Imaizumi A, Mori N
Eur J Haematol
. 2017 Aug;
99(6):495-504.
PMID: 28833639
Background: Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). Viral Tax protein plays a major role in ATL development. Pim family of serine/threonine kinases is composed...
14.
Nakayama A, Morita H, Nakao T, Yamaguchi T, Sumida T, Ikeda Y, et al.
PLoS One
. 2015 Sep;
10(9):e0137106.
PMID: 26327560
Oxidative stress has been implicated in cardiac remodeling (cardiac fibrosis and hypertrophy), which impairs cardiac function and metabolism; therefore, it is anticipated antioxidative compounds will have protective properties against cardiac...
15.
Nakagawa Y, Mukai S, Yamada S, Matsuoka M, Tarumi E, Hashimoto T, et al.
J Orthop Sci
. 2014 Oct;
19(6):933-9.
PMID: 25308211
Background: We previously developed a surface-controlled water-dispersible form of curcumin and named it Theracurmin(®) (Theracurmin; Theravalues, Tokyo, Japan). The area under the blood concentration-time curve of Theracurmin in humans was...
16.
Nazari Q, Takada-Takatori Y, Hashimoto T, Imaizumi A, Izumi Y, Akaike A, et al.
Food Funct
. 2014 Mar;
5(5):984-9.
PMID: 24637610
Curcumin, a polyphenolic compound has several pharmacological activities, such as anticancer, anti-inflammatory and antioxidant effects. However, curcumin shows poor oral bioavailability. The purpose of this study was to investigate the...
17.
Nazari Q, Kume T, Izuo N, Takada-Takatori Y, Imaizumi A, Hashimoto T, et al.
Biol Pharm Bull
. 2013 Aug;
36(8):1356-62.
PMID: 23902979
Curcumin, a polyphenolic compound extracted from Curcuma longa, has several pharmacological activities such as anticancer, anti-inflammatory, and antioxidant effects. The purpose of this study was to investigate the protective effects...
18.
Hashimoto T, Suzuki K, Kihara Y, Iwatsubo T, Miyashita A, Heeringa M, et al.
Xenobiotica
. 2012 Nov;
43(6):534-47.
PMID: 23167531
1. The absorption, metabolism and excretion of darexaban (YM150), a novel oral direct factor Xa inhibitor, were investigated after a single oral administration of [(14)C]darexaban maleate at a dose of...
19.
Izumi Y, Matsumura A, Wakita S, Akagi K, Fukuda H, Kume T, et al.
Free Radic Biol Med
. 2012 Jul;
53(4):669-79.
PMID: 22749808
The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway is a cellular defense system against oxidative stress. Activation of this pathway increases expression of antioxidant enzymes. Epidemiological...
20.
Shiraga T, Yajima K, Teragaki T, Suzuki K, Hashimoto T, Iwatsubo T, et al.
Biol Pharm Bull
. 2012 Mar;
35(3):413-21.
PMID: 22382330
Darexaban maleate is a novel oral direct factor Xa inhibitor. Darexaban glucuronide (YM-222714) was the major component in plasma after oral administration of darexaban to humans and is the pharmacologically...