T Weiser
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Explore the profile of T Weiser including associated specialties, affiliations and a list of published articles.
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34
Citations
401
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Recent Articles
11.
Weiser T, Wienrich M, Brenner M, Kubiak R, Weckesser G, Palluk R
Eur J Pharmacol
. 2001 Aug;
421(3):165-70.
PMID: 11516432
In this study, we investigated whether the novel neuroprotective compound dimethyl-[2-[2-(3-phenyl-[1,2,4]oxadiazol-5-yl)-phenoxy]-ethyl]-amine hydrochloride, BIIR 561 CL, a combined non-competitive antagonist of AMPA receptors and blocker of voltage-gated Na+ channels, is protective...
12.
Wienrich M, Brenner M, Loscher W, Palluk R, Pieper M, Potschka H, et al.
Br J Pharmacol
. 2001 Jul;
133(6):789-96.
PMID: 11454651
Glutamate receptors of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) subtype and voltage-gated Na(+) channels are associated with diseases of the central nervous system characterized by neuronal over-excitation as in epilepsy or cerebral...
13.
Weiser T, Iizuka M, Nishimura S, AKIBA I, Barsoumian E, Zhou M, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 2000 Dec;
362(4-5):419-26.
PMID: 11111837
BIIR 561 CL is a novel blocker of AMPA receptors and voltage-dependent sodium channels. In this study we further describe the effects of BIIR 561 CL on AMPA receptor-mediated membrane...
14.
Weiser T, Wieland H, Doods H
Eur J Pharmacol
. 2000 Sep;
404(1-2):133-6.
PMID: 10980271
We previously reported that (S)-N(2)-[[1-[2-[4-[(R,S)-5, 11-dihydro-6(6h)-oxodibenz[b, e]azepin-11-yl]-1-piperazinyl]-2-oxoethyl]cylopentyl]a cetyl]-N-[2-[1, 2-dihydro-3,5(4H)-dioxo-1,2-diphenyl-3H-1,2, 4-triazol-4-yl]ethyl]argininamid, BIIE0246, is a potent and highly selective neuropeptide Y Y(2) receptor antagonist. Neuropeptide Y Y(2) receptors have been proposed to...
15.
Carter A, Grauert M, Pschorn U, Bechtel W, Qu Y, Scheuer T, et al.
Proc Natl Acad Sci U S A
. 2000 Apr;
97(9):4944-9.
PMID: 10781102
We have synthesized a new benzomorphan derivative, 2R-[2alpha,3(S*), 6alpha]-1,2,3,4,5,6-hexahydro-6,11, 11-trimethyl-3-[2-(phenylmethoxy)propyl]-2, 6-methano-3-benzazocin-10-ol hydrochloride (BIII 890 CL), which displaced [(3)H]batrachotoxinin A-20alpha-benzoate from neurotoxin receptor site 2 of the Na(+) channel in rat...
16.
Seifert G, Zhou M, Dietrich D, Schumacher T, Dybek A, Weiser T, et al.
Neuropharmacology
. 2000 Mar;
39(6):931-42.
PMID: 10727703
AMPA-receptor (AMPA-R) currents were recorded from CA1 pyramidal neurons in situ and after acute isolation from the hippocampus of 3- to 45-day-old rats. Membrane currents were analyzed by combining the...
17.
Sallmann S, Juttler E, Prinz S, Petersen N, Knopf U, Weiser T, et al.
J Neurosci
. 2000 Jan;
20(23):8637-42.
PMID: 11102468
Interleukin-6 (IL-6) has neuromodulatory and neuroprotective effects in vivo. It is expressed in glial cells and neurons both under physiological conditions and in various neurological diseases. Although the expression of...
18.
Weiser T, Qu Y, Catterall W, Scheuer T
Mol Pharmacol
. 1999 Nov;
56(6):1238-44.
PMID: 10570051
Mexiletine is a class I antiarrhythmic drug with neuroprotective effects in models of brain ischemia attributable to inhibition of brain sodium channels. We compared effects of R-mexiletine on wild-type and...
19.
Draheim H, Prinz M, Weber J, Weiser T, Kettenmann H, Hanisch U
Neuroscience
. 1999 Jun;
89(4):1379-90.
PMID: 10362322
Lipopolysaccharides derived from cell walls of Gram-negative bacteria have proven a useful tool to simulate bacterial infection of the central nervous system. Rapid activation of microglia within the brain parenchyma...
20.
Weiser T, Brenner M, Palluk R, Bechtel W, Ceci A, Brambilla A, et al.
J Pharmacol Exp Ther
. 1999 May;
289(3):1343-9.
PMID: 10336525
Antagonists of glutamate receptors of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) subtype, as well as of voltage-gated sodium channels, exhibit anticonvulsive and neuroprotective properties in vivo. One can postulate that a compound...