T W North
Overview
Explore the profile of T W North including associated specialties, affiliations and a list of published articles.
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Articles
37
Citations
451
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Recent Articles
1.
Leutenegger C, Higgins J, MATTHEWS T, Tarantal A, Luciw P, Pedersen N, et al.
AIDS Res Hum Retroviruses
. 2001 Feb;
17(3):243-51.
PMID: 11177407
We developed a rapid and highly reproducible assay based on real-time PCR (TaqMan, Applied Biosystems, Foster City, CA) to quantitate simian immunodeficiency virus (SIV) RNA in plasma samples. This assay...
2.
Klarmann G, Smith R, Schinazi R, North T, Preston B
J Biol Chem
. 2000 Jan;
275(1):359-66.
PMID: 10617626
Studies of drug-resistant reverse transcriptases (RTs) reveal the roles of specific structural elements and amino acids in polymerase function. To characterize better the effects of RT/template interactions on dNTP substrate...
3.
Smith R, Klarmann G, Stray K, von Schwedler U, Schinazi R, Preston B, et al.
Antimicrob Agents Chemother
. 1999 Aug;
43(8):2077-80.
PMID: 10428942
A P157S mutation in the reverse transcriptase (RT) of human immunodeficiency virus type 1 conferred fivefold resistance to (-)-beta-2',3'-dideoxy-3'-thiacytidine in cell culture. Interestingly, the P157S mutation resulted in increased sensitivity...
4.
Elder J, Dean G, Hoover E, Hoxie J, Malim M, Mathes L, et al.
AIDS Res Hum Retroviruses
. 1998 Jun;
14(9):797-801.
PMID: 9643379
No abstract available.
5.
Smith R, Remington K, Preston B, Schinazi R, North T
J Virol
. 1998 Mar;
72(3):2335-40.
PMID: 9499094
Mutants of feline immunodeficiency virus (FIV) resistant to (-)-beta-2',3'-dideoxy-3'-thiacytidine (3TC) were selected by culturing virus in the presence of increasing stepwise concentrations of 3TC. Two plaque-purified variants were isolated from...
6.
Hartmann K, Ferk G, North T, Pedersen N
Antiviral Res
. 1997 Oct;
36(1):11-25.
PMID: 9330757
9-[(2R,5R-2,5-dihydro-5-phosphonomethoxy)-2-furanyl]adenine, or D4API, was tested in the feline immunodeficiency virus (FIV) infection model and found to be significantly more inhibitory in vitro than its parent compound 9-phosphonylmethoxethyl adenine (PMEA). Cytotoxicity...
7.
Smith R, Remington K, Lloyd Jr R, Schinazi R, North T
J Virol
. 1997 Mar;
71(3):2357-62.
PMID: 9032372
Variants of feline immunodeficiency virus (FIV) that possess a unique methionine-to-threonine mutation within the YMDD motif of reverse transcriptase (RT) were selected by culturing virus in the presence of inhibitory...
8.
Arts E, Stetor S, Li X, Rausch J, Howard K, Ehresmann B, et al.
Proc Natl Acad Sci U S A
. 1996 Sep;
93(19):10063-8.
PMID: 8816751
Initiation of minus (-) strand DNA synthesis was examined on templates containing R, U5, and primer-binding site regions of the human immunodeficiency virus type 1 (HIV-1), feline immunodeficiency virus (FIV),...
9.
Zhu Y, Remington K, North T
Antimicrob Agents Chemother
. 1996 Sep;
40(9):1983-7.
PMID: 8878567
We selected mutants of feline immunodeficiency virus (FIV) that are resistant to 2',3'-dideoxy-2',3'-didehydrothymidine (d4T). Two mutants were selected in cultured cells with a stepwise increase in d4T concentration, resulting in...
10.
Chen H, McBroom D, Zhu Y, Gold L, North T
Biochemistry
. 1996 May;
35(21):6923-30.
PMID: 8639644
High-affinity, high-specificity RNA ligands for reverse transcriptase from feline immunodeficiency virus (FIV) were isolated from an RNA library by the SELEX (Systematic Evolution of Ligands by EXponential enrichment) procedure. The...