T S Shoupe
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Explore the profile of T S Shoupe including associated specialties, affiliations and a list of published articles.
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18
Citations
69
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Recent Articles
1.
Herd C, Shoupe T, Burroughs D, Yeadon M, Page C
Br J Pharmacol
. 1994 May;
112(1):292-8.
PMID: 8032653
1. The effect of a single intratracheal dose (10 mg) of PF 5901 (2-[3(1-hydroxyhexyl) phenoxymethyl] quinoline hydrochloride, a specific inhibitor of the 5-lipoxygenase pathway of arachidonic acid metabolism and a...
2.
Herd C, Shoupe T, Kilfeather S, Okiji S, Page C
Br J Pharmacol
. 1994 Jan;
111(1):7-12.
PMID: 8012726
1. PF 10040 displaced [3H]-PAF from binding sites on rabbit platelets with an IC50 = 1.07 x 10(-5) M, which was approximately three orders of magnitude below that of a...
3.
Wallace J, McKnight G, Shoupe T, Granger D
J Lipid Mediat
. 1993 Jun;
7(2):183-96.
PMID: 8400119
The effects and mechanism of action of PF-10040, a quinoline derivative, were examined in an experimental model of NSAID-gastritis. Oral pretreatment with PF-10040 dose-dependently reduced the severity of indomethacin-induced gastric...
4.
Herd C, Shoupe T, Page C
Br J Pharmacol
. 1992 Dec;
107(4):1108-15.
PMID: 1467833
1. Aerosol administration of platelet activating factor (PAF) (80 micrograms ml-1 for 60 min) to neonatally immunized rabbits caused bronchoconstriction which was far in excess of that produced by a...
5.
Rossi A, Norman K, Shoupe T, Edwards R, Williams T
Br J Pharmacol
. 1992 Sep;
107(1):44-9.
PMID: 1330163
1. The mechanisms underlying oedema formation induced in a reversed passive Arthus (RPA) reaction and, for comparison, in response to zymosan in rabbit skin were investigated. 2. Oedema formation at...
6.
Hogaboam C, Shoupe T, Wallace J
Eur J Pharmacol
. 1992 Jun;
216(2):315-8.
PMID: 1397016
PF-5901, a novel anti-inflammatory compound, has previously been shown to inhibit the synthesis of platelet-activating factor (PAF) by peritoneal mast cells in vitro. The purpose of the present study was...
7.
Hogaboam C, Shoupe T, Bissonnette E, Befus A, Wallace J
Br J Pharmacol
. 1992 Jan;
105(1):87-92.
PMID: 1596692
1. Peritoneal mast cells from rat were co-incubated in vitro in a platelet aggregometer cuvette with washed rabbit platelets. In response to stimulation with calcium ionophore (A23187; 1-5 microM), the...
8.
Wallace J, Keenan C, Gale D, Shoupe T
Gastroenterology
. 1992 Jan;
102(1):18-27.
PMID: 1309357
The ability of nonsteroidal anti-inflammatory drugs to exacerbate experimental colitis, and the possible contributions of the "shunting" of arachidonate via the 5-lipoxygenase pathway, were investigated using a rat model in...
9.
Huang F, Shoupe T, Lin C, Lee T, Chan W, Tan J, et al.
J Med Chem
. 1989 Aug;
32(8):1836-42.
PMID: 2502629
The synthesis of a series of novel substituted hydroxamates has been described along with their profile of inhibitory activity against 5-lipoxygenase, 12-lipoxygenase, and cyclooxygenase enzymes. The structure--activity relationship suggests that...
10.
Coutts S, Khandwala A, Shoupe T, Musser J, Klunk L, Weinryb I
Agents Actions
. 1986 Jun;
18(3-4):318-24.
PMID: 2428220
CHBZ is a novel, non-disodium cromoglycate (DSCG)-like, antiallergic drug in vitro. Whereas DSCG loses antisecretory activity with increasing time of preincubation with rat mast cells (RMC) before antigen challenge, and...