T R Cummins
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Explore the profile of T R Cummins including associated specialties, affiliations and a list of published articles.
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Articles
49
Citations
2489
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Recent Articles
1.
Barbosa C, Cummins T
Curr Top Membr
. 2016 Sep;
78:599-638.
PMID: 27586296
Pain is a serious health problem that impacts the lives of many individuals. Hyperexcitability of peripheral sensory neurons contributes to both acute and chronic pain syndromes. Because voltage-gated sodium currents...
2.
Gracias N, Cummins T, Kelley M, Basile D, Iqbal T, Vasko M
Neurotoxicology
. 2010 Oct;
32(1):140-9.
PMID: 20932997
Peripheral neuropathy is a major side effect following treatment with the cancer chemotherapeutic drug paclitaxel. Whether paclitaxel-induced peripheral neuropathy is secondary to altered function of small diameter sensory neurons remains...
3.
Dib-Hajj S, Rush A, Cummins T, Hisama F, Novella S, Tyrrell L, et al.
Brain
. 2005 Jun;
128(Pt 8):1847-54.
PMID: 15958509
Erythromelalgia is an autosomal dominant disorder characterized by burning pain in response to warm stimuli or moderate exercise. We describe a novel mutation in a family with erythromelalgia in SCN9A,...
4.
Cummins T, Renganathan M, Stys P, Herzog R, Scarfo K, Horn R, et al.
Neurology
. 2003 Jan;
60(2):224-9.
PMID: 12552035
Background: An endogenous pentapeptide (Gln-Tyr-Asn-Ala-Asp; QYNAD) that is present at elevated levels in human CSF from patients with demyelinating diseases has been reported to block voltage-gated sodium channels at low...
5.
Bendahhou S, Cummins T, Kula R, Fu Y, Ptacek L
Neurology
. 2002 Apr;
58(8):1266-72.
PMID: 11971097
Background: Mutations in the human skeletal muscle sodium channels are associated with hyperKPP, hypoKPP, paramyotonia congenita, and potassium-aggravated myotonia. This article describes the clinical manifestations of a patient with hyperKPP...
6.
Nitric oxide blocks fast, slow, and persistent Na+ channels in C-type DRG neurons by S-nitrosylation
Renganathan M, Cummins T, Waxman S
J Neurophysiol
. 2002 Feb;
87(2):761-75.
PMID: 11826045
C-type dorsal root ganglion (DRG) neurons express three types of Na+ currents: fast TTX-sensitive, slow TTX-resistant, and persistent TTX-resistant Na+ currents. The nitric oxide (NO) donors papa-NONOate and S-nitroso-N-acetyl-DL-penicillamine inhibit...
7.
Everill B, Cummins T, Waxman S, Kocsis J
Neuroscience
. 2001 Sep;
106(1):161-9.
PMID: 11564426
Voltage-dependent Na-currents were studied, using whole cell voltage clamp, in acutely dissociated, large (mostly Abeta-fiber type) cutaneous afferent dorsal root ganglia neurons (L(4) and L(5)) from the adult rat. Cells...
8.
Bendahhou S, Cummins T, Griggs R, Fu Y, Ptacek L
Ann Neurol
. 2001 Sep;
50(3):417-20.
PMID: 11558801
A novel mutation in a family with hypokalemic periodic paralysis is described. The mutation R672S is located in the voltage sensor segment S4 of domain II in the SCN4A gene...
9.
Herzog R, Cummins T, Waxman S
J Neurophysiol
. 2001 Sep;
86(3):1351-64.
PMID: 11535682
Small dorsal root ganglion (DRG) neurons, which include nociceptors, express multiple voltage-gated sodium currents. In addition to a classical fast inactivating tetrodotoxin-sensitive (TTX-S) sodium current, many of these cells express...
10.
Renganathan M, Cummins T, Waxman S
J Neurophysiol
. 2001 Aug;
86(2):629-40.
PMID: 11495938
C-type dorsal root ganglion (DRG) neurons can generate tetrodotoxin-resistant (TTX-R) sodium-dependent action potentials. However, multiple sodium channels are expressed in these neurons, and the molecular identity of the TTX-R sodium...