T P Zimmerman
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Explore the profile of T P Zimmerman including associated specialties, affiliations and a list of published articles.
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62
Citations
410
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Recent Articles
1.
Zimmerman T
Vox Sang
. 2006 Nov;
91(4):309-15.
PMID: 17105606
Background And Objectives: The aim of this study was to increase the yield of active alpha(1)-proteinase inhibitor (alpha(1)-PI) from Cohn fraction IV-1 paste during the manufacture of this therapeutic protein...
2.
Novokhatny V, Taylor K, Zimmerman T
J Thromb Haemost
. 2003 Jul;
1(5):1034-41.
PMID: 12871374
Plasmin, the direct fibrinolytic enzyme, was compared with tissue plasminogen activator (t-PA) in an in vitro thrombolysis model. Plasmin has been prepared in a highly pure form from human plasma...
3.
Marder V, Landskroner K, Novokhatny V, Zimmerman T, Kong M, Kanouse J, et al.
Thromb Haemost
. 2001 Oct;
86(3):739-45.
PMID: 11583303
The direct fibrinolytic enzyme, plasmin, was compared with tissue plasminogen activator (TPA) in rabbit models of local thrombolysis and fibrinolytic hemorrhage. Plasmin was produced by solid-phase urokinase activation of plasminogen...
4.
Porter D, Harrington J, Almond M, Lowen G, Zimmerman T, Spector T
Biochem Pharmacol
. 1994 Mar;
47(7):1165-71.
PMID: 8161345
5-Ethynyluracil is a potent mechanism-based inactivator of dihydropyrimidine dehydrogenase (DPD, EC 1.3.1.2) in vitro (Porter et al., J Biol Chem 267: 5236-5242, 1992) and in vivo (Spector et al., Biochem...
5.
Domin B, Mahony W, Zimmerman T
Biochem Pharmacol
. 1993 Aug;
46(4):725-9.
PMID: 8363645
The mechanism of membrane permeation of several 2',3'-dideoxynucleosides was investigated at 37 degrees with human erythrocytes using an "inhibitor-stop" assay. Transport (per 5 microL cells) via the nucleoside and nucleobase...
6.
Domin B, Mahony W, Zimmerman T
Biochem Pharmacol
. 1993 Aug;
46(3):503-10.
PMID: 8347174
The transport of 5-fluorouracil (5-FU) and uracil into human erythrocytes has been investigated under initial velocity conditions with an "inhibitor-stop" assay using a cold papaverine solution to terminate influx. At...
7.
Zimmerman T, Domin B, Mahony W
Oncol Res
. 1993 Jan;
5(12):483-7.
PMID: 8086670
3'-Azido-3'-deoxythymidine (AZT) competitively inhibited the transport of thymidine (Km = 0.23 mM) into human erythrocytes with a Ki of 1.0 mM at 37 degrees C. The principal human metabolite of...
8.
Mahony W, Domin B, Daluge S, Miller W, Zimmerman T
J Biol Chem
. 1992 Oct;
267(28):19792-7.
PMID: 1400293
Carbovir (9-[4 alpha-(hydroxymethyl)cyclopent-2-ene-1 alpha-yl]guanine) (CBV) is a carbocyclic analogue of 2',3'-dideoxyguanosine that exhibits potent and selective in vitro activity against human immunodeficiency virus. Antiviral activity is associated with only the...
9.
Domin B, Mahony W, Koszalka G, Porter D, Hajian G, Zimmerman T
Mol Pharmacol
. 1992 May;
41(5):950-6.
PMID: 1588925
The membrane permeation characteristics of 5'-deoxythymidine (5'-ddThd) and 5'-azido-5'-deoxythymidine (5'-N3-5'-ddThd) were investigated in human erythrocytes, with an inhibitor-stop assay, at 20 degrees. Uptake of both nucleoside analogs occurred without metabolism,...
10.
Prus K, Heidenreich A, Zimmerman T
Antimicrob Agents Chemother
. 1992 Feb;
36(2):283-6.
PMID: 1318676
The transport of the anti-varicella-zoster virus agent 6-methoxypurine arabinoside and its 2'-O-valerate prodrug, 170U88, was investigated by using the human erythrocyte model. The influx of 6-methoxypurine arabinoside was found to...