T M Willson
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Explore the profile of T M Willson including associated specialties, affiliations and a list of published articles.
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75
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12065
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Recent Articles
1.
Ngala R, Stocker C, Roy A, Hislop D, Wargent E, Bell R, et al.
Diabetes Obes Metab
. 2011 Jan;
13(5):455-64.
PMID: 21272187
Aim: We investigated how GW800644, the first pharmacologically selective murine peroxisome proliferator-activated receptor δ (PPARδ) agonist, affects energy balance, glucose homeostasis and fuel utilization by muscle in obese mice. Methods:...
2.
Furnsinn C, Willson T, Brunmair B
Diabetologia
. 2006 Nov;
50(1):8-17.
PMID: 17119917
Synthetic agonists of peroxisome proliferator-activated receptor (PPAR)-delta have shown a promising pharmacological profile in preclinical models of metabolic and cardiovascular disease. At present, the pharmaceutical development of these drugs exploits...
3.
Kim D, Bility M, Billin A, Willson T, Gonzalez F, Peters J
Cell Death Differ
. 2005 Jul;
13(1):53-60.
PMID: 16021179
Peroxisome proliferator-activated receptor (PPAR) beta-null mice exhibit exacerbated epithelial cell proliferation and enhanced sensitivity to skin carcinogenesis, suggesting that ligand activation of PPARbeta will inhibit keratinocyte proliferation. By using of...
4.
Liu K, Lambert M, Ayscue A, Henke B, Leesnitzer L, Oliver Jr W, et al.
Bioorg Med Chem Lett
. 2001 Nov;
11(24):3111-3.
PMID: 11720854
A series of PPARgamma agonists were synthesized from L-tyrosine that incorporated low molecular weight N-substituents. The most potent analogue, pyrrole (4e), demonstrated a K(i) of 6.9nM and an EC(50) of...
5.
Xu H, Lambert M, Montana V, Plunket K, Moore L, Collins J, et al.
Proc Natl Acad Sci U S A
. 2001 Nov;
98(24):13919-24.
PMID: 11698662
The peroxisome proliferator-activated receptors (PPARs) are transcriptional regulators of glucose, lipid, and cholesterol metabolism. We report the x-ray crystal structure of the ligand binding domain of PPAR alpha (NR1C1) as...
6.
Liu K, Lambert M, Leesnitzer L, Oliver Jr W, Ott R, Plunket K, et al.
Bioorg Med Chem Lett
. 2001 Oct;
11(22):2959-62.
PMID: 11677135
We have developed a general solid-phase synthesis for identification of PPAR ligands. Synthesis of a 480-member library led to the identification of a potent PPAR gamma/delta dual agonist 23. Compound...
7.
Willson T, Jones S, Moore J, Kliewer S
Med Res Rev
. 2001 Oct;
21(6):513-22.
PMID: 11607932
Chemical genomics is the name we have given to the analysis of gene function through use of small molecule chemical tools. Orphan nuclear receptors are ideally suited to this technique...
8.
Fu M, Zhang J, Zhu X, Myles D, Willson T, Liu X, et al.
J Biol Chem
. 2001 Oct;
276(49):45888-94.
PMID: 11590167
Activation of peroxisome proliferator-activated receptor gamma (PPAR gamma) after balloon injury significantly inhibits VSMC proliferation and neointima formation. However, the precise mechanisms of this inhibition have not been determined. We...
9.
Kast H, Nguyen C, Sinal C, Jones S, Laffitte B, Reue K, et al.
Mol Endocrinol
. 2001 Oct;
15(10):1720-8.
PMID: 11579204
The farnesoid X-activated receptor (FXR; NR1H4), a member of the nuclear hormone receptor superfamily, induces gene expression in response to several bile acids, including chenodeoxycholic acid. Here we used suppression...
10.
Whitney K, Watson M, Goodwin B, Galardi C, Maglich J, Wilson J, et al.
J Biol Chem
. 2001 Sep;
276(47):43509-15.
PMID: 11546778
The nuclear oxysterol receptors LXRalpha (NR1H3) and LXRbeta (NR1H2) coordinately regulate the expression of genes involved in the transport and catabolism of cholesterol. In macrophages, LXR stimulates the transcription of...