T L Nagabhushan
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Explore the profile of T L Nagabhushan including associated specialties, affiliations and a list of published articles.
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54
Citations
802
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Recent Articles
1.
Huang E, Pramanik B, Tsarbopoulos A, Reichert P, Ganguly A, Trotta P, et al.
J Am Soc Mass Spectrom
. 2013 Nov;
4(8):624-30.
PMID: 24227665
A novel mass spectrometry-based methodology using electrospray ionization (ESI) is described for the detection of protein-protein [interferon (IFN)-γ dimer] and protein-ligand [ras-guanosine diphosphate (GDP)] noncovalent interactions. The method utilizes ESI...
2.
Nagabhushan T, Maneval D, Benedict W, Wen S, Ihnat P, Engler H, et al.
Cytokine Growth Factor Rev
. 2007 Aug;
18(5-6):389-94.
PMID: 17692556
Intravesical administration of interferon alpha-2b protein (IFN) has been successfully used in the treatment of patients with superficial bladder tumors. Local dosing of IFN minimizes well-known systemic side effects of...
3.
Brassard D, English J, Malkowski M, Kirschmeier P, Nagabhushan T, Bishop W
Exp Cell Res
. 2002 Feb;
273(2):138-46.
PMID: 11822869
Farnesyl protein transferase inhibitors (FTIs) reverse the transformed phenotype of fibroblasts expressing activated H-Ras and block anchorage-independent growth and tumorigenesis of tumor cell lines independent of their Ras mutational status....
4.
Ahmed C, Johnson D, Demers G, Engler H, Howe J, Wills K, et al.
Cancer Gene Ther
. 2001 Nov;
8(10):788-95.
PMID: 11687902
A recombinant adenovirus expressing human interferon alpha2b driven by the cytomegalovirus promoter, IACB, was shown to produce and secrete biologically active protein in vitro and in vivo. Intravenous administration of...
5.
Ahmed C, Wills K, Sugarman B, Johnson D, Ramachandra M, Nagabhushan T, et al.
J Interferon Cytokine Res
. 2001 Jul;
21(6):399-408.
PMID: 11440637
Replication-deficient adenoviruses expressing human interferon-alpha2b (HuIFN-alpha2b) or the hybrid IFN-alpha2alpha1 or those with the secretory signal deleted, whose express is driven by the alpha-fetoprotein (AFP) promoter, were constructed and characterized....
6.
Connor R, Engler H, Machemer T, Philopena J, Horn M, Sutjipto S, et al.
Gene Ther
. 2001 Jun;
8(1):41-8.
PMID: 11402300
Adenovirus-mediated gene therapy of bladder diseases has been limited by the inability to transduce the urothelium successfully using adenoviral vectors. We have sought to identify agents that would increase adenovirus-mediated...
7.
Landar A, Curry B, Parker M, Digiacomo R, Indelicato S, Nagabhushan T, et al.
J Mol Biol
. 2000 Jun;
299(1):169-79.
PMID: 10860730
A mutant form of human interferon-gamma (IFN-gamma SC1) that binds one IFN-gamma receptor alpha chain (IFN-gamma R alpha) has been designed and characterized. IFN-gamma SC1 was derived by linking the...
8.
Walter M, Bordens R, Nagabhushan T, Williams B, Herberman R, Dinarello C, et al.
Cancer Biother Radiopharm
. 2000 Jun;
13(3):143-54.
PMID: 10850350
Recombinant alfa interferons (IFN-alpha s) are approved worldwide for the treatment of a variety of cancers and diseases of virologic origin. A series of recent advances in the molecular characterization...
9.
Josephson K, Digiacomo R, Indelicato S, Iyo A, Nagabhushan T, Parker M, et al.
J Biol Chem
. 2000 May;
275(18):13552-7.
PMID: 10788470
A monomeric form of human interleukin 10 (IL-10M1) has been engineered for detailed structure-function studies on IL-10 and its receptor complexes. Wild type IL-10 (wtIL-10) is a domain swapped dimer...
10.
Tsarbopoulos A, Varnerin J, Wylie D, Pramanik B, Tang J, Nagabhushan T
J Mass Spectrom
. 2000 Apr;
35(3):446-53.
PMID: 10767776
Interleukin 13 (IL-13), a member of the a-helical family of cytokines, has approximately 30% primary sequence homology with IL-4 and shares a common receptor component. The biologically active rhIL-13 is...