T L Madden
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Explore the profile of T L Madden including associated specialties, affiliations and a list of published articles.
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17
Citations
28869
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Recent Articles
1.
Wolfsberg T, Madden T
Curr Protoc Protein Sci
. 2008 Apr;
Chapter 2:Unit2.5.
PMID: 18429153
The BLAST (Basic Local Alignment Search Tool) family of sequence similarity search programs allows users to input either a nucleotide or amino acid query sequence, and search a nucleotide or...
2.
Wolfsberg T, Madden T
Curr Protoc Mol Biol
. 2008 Feb;
Chapter 19:Unit 19.3.
PMID: 18265177
Database sequence similarity searching is carried out thousands of times each day by researchers worldwide and has become a very valuable tool. Over the years, a number of algorithms have...
3.
Smith J, Cortes J, Newman R, Madden T
J Chromatogr B Biomed Sci Appl
. 2001 Sep;
760(2):247-53.
PMID: 11530983
UCN-01 is a naturally derived anticancer agent isolated in the culture broth of actinomyces streptomyces. We have developed a sensitive high-performance liquid chromatographic method for the determination of UCN-01 in...
4.
Smith J, Hausheer F, Newman R, Madden T
J Chromatogr B Biomed Sci Appl
. 2001 Aug;
759(1):117-24.
PMID: 11499615
Karenitecin is a novel, highly lipophilic camptothecin derivative with potent anticancer potential. We have developed a sensitive high-performance liquid chromatographic method for the determination of karenitecin concentration in human plasma...
5.
Schaffer A, Aravind L, Madden T, Shavirin S, Spouge J, Wolf Y, et al.
Nucleic Acids Res
. 2001 Jul;
29(14):2994-3005.
PMID: 11452024
PSI-BLAST is an iterative program to search a database for proteins with distant similarity to a query sequence. We investigated over a dozen modifications to the methods used in PSI-BLAST,...
6.
Shaikenov T, Adekenov S, Williams R, Prashad N, Baker F, Madden T, et al.
Oncol Rep
. 2000 Dec;
8(1):173-9.
PMID: 11115593
Arglabin [1(R),10(S)-epoxy-5(S),5(S),7(S)-guaia-3(4),11(13)-dien-6, 12-olide], a sesquiterpene gamma-lactone is isolated from Artemisia glabella, a species of wormwood endemic to the Karaganda region of Kazakstan. The compound has been modified to render it...
7.
Wheeler D, Church D, Lash A, Leipe D, Madden T, Pontius J, et al.
Nucleic Acids Res
. 2000 Jan;
29(1):11-6.
PMID: 11125038
In addition to maintaining the GenBank nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides data analysis and retrieval resources that operate on the data in GenBank...
8.
Wheeler D, Chappey C, Lash A, Leipe D, Madden T, Schuler G, et al.
Nucleic Acids Res
. 1999 Dec;
28(1):10-4.
PMID: 10592169
In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides data analysis and retrieval and resources that operate on the data in...
9.
Tatusova T, Madden T
FEMS Microbiol Lett
. 1999 May;
174(2):247-50.
PMID: 10339815
'BLAST 2 Sequences', a new BLAST-based tool for aligning two protein or nucleotide sequences, is described. While the standard BLAST program is widely used to search for homologous sequences in...
10.
Newman R, Chen W, Madden T
J Pharm Sci
. 1998 Sep;
87(9):1077-80.
PMID: 9724557
The present studies were undertaken to compare the relative pharmacokinetic parameters and bioavailability of two chemically related natural products which are nonnucleoside inhibitors of reverse transcriptase. Both (+)-calanolide A (Cal...