T L Madden
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Explore the profile of T L Madden including associated specialties, affiliations and a list of published articles.
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17
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28869
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Recent Articles
11.
Zhang Z, Schaffer A, Miller W, Madden T, Lipman D, Koonin E, et al.
Nucleic Acids Res
. 1998 Aug;
26(17):3986-90.
PMID: 9705509
Protein families often are characterized by conserved sequence patterns or motifs. A researcher frequently wishes to evaluate the significance of a specific pattern within a protein, or to exploit knowledge...
12.
Altschul S, Madden T, Schaffer A, Zhang J, Zhang Z, Miller W, et al.
Nucleic Acids Res
. 1997 Sep;
25(17):3389-402.
PMID: 9254694
The BLAST programs are widely used tools for searching protein and DNA databases for sequence similarities. For protein comparisons, a variety of definitional, algorithmic and statistical refinements described here permits...
13.
Kudelka A, Siddik Z, Tresukosol D, Edwards C, Freedman R, Madden T, et al.
Anticancer Drugs
. 1997 Aug;
8(7):649-56.
PMID: 9311439
This was a study of enloplatin in 18 evaluable patients with platinum refractory ovarian cancer. They received an i.v. infusion of enloplatin over 1.5 h without prehydration every 21 days....
14.
Zhang J, Madden T
Genome Res
. 1997 Jun;
7(6):649-56.
PMID: 9199938
As the rate of DNA sequencing increases, analysis by sequence similarity search will need to become much more efficient in terms of sensitivity, specificity, automation potential, and consistency in annotation....
15.
Madden T, Tatusov R, Zhang J
Methods Enzymol
. 1996 Jan;
266:131-41.
PMID: 8743682
The sequence databases continue to grow at an extraordinary rate. Contributions come from both small laboratories and large-scale projects, such as the Merck EST project. This growth has placed new...
16.
Madden T, Herzfeld J
J Cell Biol
. 1994 Jul;
126(1):169-74.
PMID: 8027175
Through calculations of molecular packing constraints in crowded solutions, we have previously shown that dispersions of filament forming proteins and soluble proteins can be unstable at physiological concentrations, such that...
17.
Madden T, Herzfeld J
Biophys J
. 1993 Sep;
65(3):1147-54.
PMID: 8241394
The theory for the effects of crowding on the behavior of reversibly self-assembling solutes is extended to mixtures containing nonassembling solutes. The theory predicts that excluded volume will cause dramatic...