T Kelly Rainbolt
Overview
Explore the profile of T Kelly Rainbolt including associated specialties, affiliations and a list of published articles.
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10
Citations
527
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Recent Articles
1.
Elsasser S, Elia L, Morimoto R, Powers E, Finley D, Costa B, et al.
bioRxiv
. 2023 Mar;
PMID: 36993380
The condition of having a healthy, functional proteome is known as protein homeostasis, or proteostasis. Establishing and maintaining proteostasis is the province of the proteostasis network, approximately 2,700 components that...
2.
Stein K, Morales-Polanco F, van der Lienden J, Rainbolt T, Frydman J
Nature
. 2022 Jan;
601(7894):637-642.
PMID: 35046576
Ageing is accompanied by a decline in cellular proteostasis, which underlies many age-related protein misfolding diseases. Yet, how ageing impairs proteostasis remains unclear. As nascent polypeptides represent a substantial burden...
3.
Vonk W, Rainbolt T, Dolan P, Webb A, Brunet A, Frydman J
Mol Cell
. 2020 Apr;
78(2):329-345.e9.
PMID: 32268122
Neural stem and progenitor cells (NSPCs) are critical for continued cellular replacement in the adult brain. Lifelong maintenance of a functional NSPC pool necessitates stringent mechanisms to preserve a pristine...
4.
Rainbolt T, Frydman J
Proc Natl Acad Sci U S A
. 2020 Feb;
117(7):3352-3354.
PMID: 32019880
No abstract available.
5.
Taguwa S, Yeh M, Rainbolt T, Nayak A, Shao H, Gestwicki J, et al.
Cell Rep
. 2019 Jan;
26(4):906-920.e3.
PMID: 30673613
The spread of mosquito-borne Zika virus (ZIKV), which causes neurological disorders and microcephaly, highlights the need for countermeasures against sudden viral epidemics. Here, we tested the concept that drugs targeting...
6.
Lebeau J, Rainbolt T, Wiseman R
Int Rev Cell Mol Biol
. 2018 Aug;
340:79-128.
PMID: 30072094
Proteases are localized throughout mitochondria and function as critical regulators of all aspects of mitochondrial biology. As such, the activities of these proteases are sensitively regulated through transcriptional and post-translational...
7.
Rainbolt T, Lebeau J, Puchades C, Wiseman R
Cell Rep
. 2016 Mar;
14(9):2041-2049.
PMID: 26923599
The mitochondrial inner membrane proteases YME1L and OMA1 are critical regulators of essential mitochondrial functions, including inner membrane proteostasis maintenance and mitochondrial dynamics. Here, we show that YME1L and OMA1...
8.
Rainbolt T, Saunders J, Wiseman R
EMBO Rep
. 2014 Nov;
16(1):97-106.
PMID: 25433032
Mitochondrial proteostasis is maintained by a network of ATP-dependent quality control proteases including the inner membrane protease YME1L. Here, we show that YME1L is a stress-sensitive mitochondrial protease that is...
9.
Rainbolt T, Saunders J, Wiseman R
Trends Endocrinol Metab
. 2014 Jul;
25(10):528-37.
PMID: 25048297
The endoplasmic reticulum (ER) and mitochondria form physical interactions involved in the regulation of biologic functions including mitochondrial bioenergetics and apoptotic signaling. To coordinate these functions during stress, cells must...
10.
Rainbolt T, Atanassova N, Genereux J, Wiseman R
Cell Metab
. 2013 Dec;
18(6):908-19.
PMID: 24315374
Stress-regulated signaling pathways protect mitochondrial proteostasis and function from pathologic insults. Despite the importance of stress-regulated signaling pathways in mitochondrial proteome maintenance, the molecular mechanisms by which these pathways maintain...