Steve Finkbeiner
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Explore the profile of Steve Finkbeiner including associated specialties, affiliations and a list of published articles.
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14
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487
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Recent Articles
1.
Stocksdale J, Leventhal M, Lam S, Xu Y, Wang Y, Wang K, et al.
bioRxiv
. 2025 Mar;
PMID: 40060574
Huntington's Disease (HD) is caused by a CAG repeat expansion in the gene encoding Huntingtin (HTT . While normal HTT function appears impacted by the mutation, the specific pathways unique...
2.
Tsitkov S, Valentine K, Kozareva V, Donde A, Frank A, Lei S, et al.
Nat Commun
. 2024 May;
15(1):3606.
PMID: 38697975
Amyotrophic Lateral Sclerosis (ALS), like many other neurodegenerative diseases, is highly heritable, but with only a small fraction of cases explained by monogenic disease alleles. To better understand sporadic ALS,...
3.
Elsasser S, Elia L, Morimoto R, Powers E, Finley D, Costa B, et al.
bioRxiv
. 2023 Mar;
PMID: 36993380
The condition of having a healthy, functional proteome is known as protein homeostasis, or proteostasis. Establishing and maintaining proteostasis is the province of the proteostasis network, approximately 2,700 components that...
4.
Matlock A, Vaibhav V, Holewinski R, Venkatraman V, Dardov V, Manalo D, et al.
Sci Data
. 2023 Jan;
10(1):24.
PMID: 36631473
The National Institute of Health (NIH) Library of integrated network-based cellular signatures (LINCS) program is premised on the generation of a publicly available data resource of cell-based biochemical responses or...
5.
Barbe L, Finkbeiner S
Front Aging Neurosci
. 2022 May;
14:750629.
PMID: 35592702
Repeat diseases, such as fragile X syndrome, myotonic dystrophy, Friedreich ataxia, Huntington disease, spinocerebellar ataxias, and some forms of amyotrophic lateral sclerosis, are caused by repetitive DNA sequences that are...
6.
Stormo A, Shavarebi F, Fitzgibbon M, Earley E, Ahrendt H, Lum L, et al.
J Cell Biol
. 2022 Mar;
221(4).
PMID: 35266954
Missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease (PD); however, pathways regulating LRRK2 subcellular localization, function, and turnover are not fully...
7.
Kaye J, Reisine T, Finkbeiner S
Fac Rev
. 2021 Nov;
10:77.
PMID: 34746930
Huntington's disease (HD) is a neurodegenerative disease that results in motor and cognitive dysfunction, leading to early death. HD is caused by an expansion of CAG repeats in the huntingtin...
8.
Reed X, Cobb M, Skinbinski G, Roosen D, Kaganovich A, Ding J, et al.
Stem Cell Res
. 2021 Oct;
56:102558.
PMID: 34626895
Reproducibility of expression patterns in iPSC-derived cells from different labs is an important first step in ensuring replication of biochemical or functional assays that are performed in different labs. Here...
9.
Li H, Doric Z, Berthet A, Jorgens D, Nguyen M, Hsieh I, et al.
Sci Adv
. 2021 Aug;
7(32).
PMID: 34362731
Altered mitochondrial quality control and dynamics may contribute to neurodegenerative diseases, including Parkinson's disease, but we understand little about these processes in neurons. We combined time-lapse microscopy and correlative light...
10.
Fontaine K, Leon K, Khalid M, Tomar S, Jimenez-Morales D, Dunlap M, et al.
mBio
. 2018 Nov;
9(6).
PMID: 30401782
Zika virus (ZIKV) infection of neural progenitor cells (NPCs) is associated with neurological disorders, such as microcephaly, but a detailed molecular understanding of ZIKV-induced pathogenesis is lacking. Here we show...