T J Van Berkel
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Explore the profile of T J Van Berkel including associated specialties, affiliations and a list of published articles.
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258
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3066
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Recent Articles
1.
Rump E, Biessen E, Van Berkel T, Bijsterbosch M
Methods Mol Med
. 2011 Feb;
65:89-104.
PMID: 21318747
The ability of antisense oligonucleotides to interdict, sequence-specifically, the expression of pathogenic genes affords an exciting new strategy for therapeutic intervention (1-3). Oligonucleotides with physiological phosphodiester internucleotide bonds are rapidly...
2.
Ye D, Lammers B, Zhao Y, Meurs I, Van Berkel T, Van Eck M
Curr Drug Targets
. 2010 Nov;
12(5):647-60.
PMID: 21039336
Atherosclerosis has been characterized as a chronic inflammatory response to cholesterol deposition in arteries. Plasma high density lipoprotein (HDL) levels bear a strong independent inverse relationship with atherosclerotic cardiovascular disease....
3.
Krom Y, Gras J, Frants R, Havekes L, Van Berkel T, Biessen E, et al.
Biochem Biophys Res Commun
. 2005 Nov;
338(2):847-54.
PMID: 16259946
Vascular smooth muscle (VSMC) and endothelial cells (EC) are particularly resistant to infection by type 5 adenovirus (Ad) vectors. To overcome this limitation and target Ad vectors to ubiquitously expressed...
4.
van Oosten M, van Amersfoort E, Van Berkel T, Kuiper J
J Endotoxin Res
. 2001 Dec;
7(5):381-4.
PMID: 11753207
This study was undertaken to identify the role of scavenger receptors in the catabolism of lipopolysaccharide (LPS) and lipoteichoic acid (LTA). LPS is mainly cleared from the blood by the...
5.
Hoen P, Bijsterbosch M, Van Berkel T, Vermeulen N, Commandeur J
J Pharmacol Exp Ther
. 2001 Nov;
299(3):921-7.
PMID: 11714877
Midazolam is almost exclusively metabolized by cytochrome P450 3A (CYP3A) isoenzymes. Therefore, midazolam is used as a probe to determine CYP3A levels in humans and rats. A prerequisite for longitudinal...
6.
von der Thusen J, Kuiper J, Fekkes M, de Vos P, Van Berkel T, Biessen E
FASEB J
. 2001 Nov;
15(14):2730-2.
PMID: 11687507
In view of its multifaceted anti-inflammatory properties, interleukin-10 (IL-10) has been deemed to be potentially anti-atherogenic. We have evaluated the capacity of adenoviral gene transfer of IL-10 for the modulation...
7.
Jong M, Rensen P, Dahlmans V, van der Boom H, Van Berkel T, Havekes L
J Lipid Res
. 2001 Oct;
42(10):1578-85.
PMID: 11590213
Previous studies with hypertriglyceridemic APOC3 transgenic mice have suggested that apolipoprotein C-III (apoC-III) may inhibit either the apoE-mediated hepatic uptake of TG-rich lipoproteins and/or the lipoprotein lipase (LPL)-mediated hydrolysis of...
8.
Bijsterbosch M, Manoharan M, Dorland R, Waarlo I, Biessen E, Van Berkel T
Biochem Pharmacol
. 2001 Oct;
62(5):627-33.
PMID: 11585059
The efficacy of antisense oligonucleotides depends on the ability to reach in vivo their target cells. We aim to develop strategies to enhance uptake of phosphorothioate oligodeoxynucleotides by Kupffer cells....
9.
Hollestelle M, Thinnes T, Crain K, Stiko A, Kruijt J, Van Berkel T, et al.
Thromb Haemost
. 2001 Oct;
86(3):855-61.
PMID: 11583319
Previous studies have shown that factor VIII (FVIII) is expressed by multiple tissues. However, little is known about its cellular origin or its level of expression in different organs. In...
10.
Bijsterbosch M, Ying C, de Vrueh R, De Clercq E, Biessen E, Neyts J, et al.
Mol Pharmacol
. 2001 Aug;
60(3):521-7.
PMID: 11502883
We recently synthesized a lipophilic prodrug of 9-(2-phosphonyl-methoxyethyl)adenine (PMEA), designated PMEA-LO, and incorporated it into reconstituted lactosylated high-density lipoprotein (LacNeoHDL). In a rat model, LacNeoHDL-associated PMEA-LO was internalized by the...