T J McDonnell
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Explore the profile of T J McDonnell including associated specialties, affiliations and a list of published articles.
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Articles
114
Citations
2774
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Recent Articles
11.
Ahmad K, McDonnell T, Rogers S
Clin Exp Dermatol
. 2007 Apr;
32(3):329.
PMID: 17397361
No abstract available.
12.
Spurgers K, Chari N, Bohnenstiehl N, McDonnell T
Cell Death Differ
. 2006 Jun;
13(8):1360-70.
PMID: 16763617
A consistent, if not invariant, feature of cancer cells is the acquired ability to evade apoptosis. The pioneering work of Dr. Stan Korsmeyer was invaluable in characterizing the molecular foundations...
13.
Butler M, OMahony M, Donnelly S, McDonnell T
Ir Med J
. 2004 Jun;
97(4):108-10.
PMID: 15200219
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a major cause of hospital admissions. Because of the consequent morbidity, mortality and burden on hospital resources, COPD management guidelines have...
14.
[Bcl-2 inhibits p53-induced apoptosis after genotoxic damage by inhibitors of nuclear import of p53]
Beham A, Schumacher G, McDonnell T, Marin M, Jauch K
Langenbecks Arch Chir Suppl Kongressbd
. 2003 Oct;
115(Suppl I):113-7.
PMID: 14518224
The tumor suppressor gene p53 in overexpressed in 50% of colorectal carcinomas and is an interesting target for gene therapeutic approaches. Furthermore the protooncogen bcl-2 is known to inhibit p53...
15.
Pisters L, Pettaway C, Hossan E, Evans R, Steiner M, Wood C, et al.
Prostate Cancer Prostatic Dis
. 2002 Dec;
2(S3):S27.
PMID: 12496806
No abstract available.
16.
Lai R, McDonnell T, OConnor S, Medeiros L, Oudat R, Keating M, et al.
Leuk Res
. 2002 Jul;
26(9):849-55.
PMID: 12127561
Mantle cell lymphoma (MCL) is a distinct type of B-cell non-Hodgkin's lymphoma characterized by cyclin D1 overexpression and the cytogenetic abnormality, the t(11;14)(q13;q32). MCL cell lines have been difficult to...
17.
Butler M, Griffin J, Quinlan W, McDonnell T
Ir J Med Sci
. 2002 Jul;
170(3):198-9.
PMID: 12120977
Background: Quinolones have traditionally had limited application in the area of community-acquired respiratory tract infections due to poor cover against Streptococcus pneumoniae. This trend is changing with the broader spectrum...
18.
Munshi A, McDonnell T, Meyn R
Cancer Chemother Pharmacol
. 2002 Jul;
50(1):46-52.
PMID: 12111111
Purpose: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) family that preferentially kills tumor cells. In this study, we sought to determine whether...
19.
Honda T, Gjertsen B, Spurgers K, Briones F, Lee S, Hobbs M, et al.
Anticancer Res
. 2002 Feb;
21(5):3141-6.
PMID: 11848465
Background: Cancer cells are characterized by multiple genetic defects which result in altered rates of cell division, cell death and ability to differentiate. These same molecular alterations may also contribute...
20.
Lowe S, Rubinchik S, Honda T, McDonnell T, Dong J, Norris J
Gene Ther
. 2001 Sep;
8(18):1363-71.
PMID: 11571575
In prostate carcinoma, overexpression of the anti-apoptotic gene Bcl-2 has been found to be associated with resistance to therapies including radiation and androgen ablation. Restoring the balance of Bcl-2 family...