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T F Osborne

Explore the profile of T F Osborne including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 45
Citations 1576
Followers 0
Related Specialties
Biochemistry
Science
Cell Biology
Top 10 Co-Authors
J L Goldstein
M S Brown
H B Sanchez
G Gil
M K Bennett
J M Rosenfeld
A J Berk
M M Magana
J R Smith
K A Dooley
Published In
J Biol Chem
Proc Natl Acad Sci U S A
Cell
Nucleic Acids Res
Mol Cell Biol
Affiliations
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Recent Articles
1.
YY1 is a positive regulator of transcription of the Col1a1 gene
Riquet F, Tan L, Choy B, Osaki M, Karsenty G, Osborne T, et al.
J Biol Chem . 2001 Aug; 276(42):38665-72. PMID: 11514536
Both cell-specific and ubiquitous transcription factors in fibroblasts have been identified as critical for expression of the Col1a1 gene, which encodes the alpha1 chain of type I collagen. Here, we...
2.
CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin
Osborne T
Genes Dev . 2001 Aug; 15(15):1873-8. PMID: 11485982
No abstract available.
3.
Transcriptional regulation of the murine acetyl-CoA synthetase 1 gene through multiple clustered binding sites for sterol regulatory element-binding proteins and a single neighboring site for Sp1
Ikeda Y, Yamamoto J, Okamura M, Fujino T, Takahashi S, Takeuchi K, et al.
J Biol Chem . 2001 Jul; 276(36):34259-69. PMID: 11435428
Cytosolic acetyl-CoA synthetase (AceCS1) activates acetate to supply the cells with acetyl-CoA for lipid synthesis. The cDNA for the mammalian AceCS1 has been isolated recently, and the mRNA was shown...
4.
Conditional response of the human steroidogenic acute regulatory protein gene promoter to sterol regulatory element binding protein-1a
Christenson L, Osborne T, McAllister J, Strauss 3rd J
Endocrinology . 2001 Jan; 142(1):28-36. PMID: 11145563
The steroidogenic acute regulatory protein (StAR) gene controls the rate-limiting step in the biogenesis of steroid hormones, delivery of cholesterol to the cholesterol side-chain cleavage enzyme on the inner mitochondrial...
5.
Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action
Osborne T
J Biol Chem . 2000 Aug; 275(42):32379-82. PMID: 10934219
No abstract available.
6.
Nutrient regulation of gene expression by the sterol regulatory element binding proteins: increased recruitment of gene-specific coregulatory factors and selective hyperacetylation of histone H3 in vivo
Bennett M, Osborne T
Proc Natl Acad Sci U S A . 2000 Jun; 97(12):6340-4. PMID: 10841543
We have evaluated the mechanism for sterol-regulated gene expression by the sterol regulatory element binding proteins (SREBPs) in intact cells. We show that activation of SREBPs by sterol depletion results...
7.
Different sterol regulatory element-binding protein-1 isoforms utilize distinct co-regulatory factors to activate the promoter for fatty acid synthase
Magana M, Koo S, Towle H, Osborne T
J Biol Chem . 2000 Feb; 275(7):4726-33. PMID: 10671504
Sterol regulatory element-binding proteins (SREBPs) activate genes of cholesterol and fatty acid metabolism. In each case, a ubiquitous co-regulatory factor that binds to a neighboring recognition site is also required...
8.
Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 protein
Bennett M, Ngo T, Athanikar J, Rosenfeld J, Osborne T
J Biol Chem . 1999 May; 274(19):13025-32. PMID: 10224053
Sterol regulation of gene expression in mammalian cells is mediated by an interaction between the cholesterol-sensitive sterol regulatory element-binding proteins (SREBPs) and promoter-specific but generic co-regulatory transcription factors such as...
9.
A critical role for cAMP response element-binding protein (CREB) as a Co-activator in sterol-regulated transcription of 3-hydroxy-3-methylglutaryl coenzyme A synthase promoter
Dooley K, Bennett M, Osborne T
J Biol Chem . 1999 Feb; 274(9):5285-91. PMID: 10026135
3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase, a key regulatory enzyme in the pathway for endogenous cholesterol synthesis, is a target for negative feedback regulation by cholesterol. When cellular sterol levels are...
10.
Oxysterol regulation of steroidogenic acute regulatory protein gene expression. Structural specificity and transcriptional and posttranscriptional actions
Christenson L, McAllister J, Martin K, JAVITT N, Osborne T, Strauss 3rd J
J Biol Chem . 1998 Nov; 273(46):30729-35. PMID: 9804848
Oxysterols exert a major influence over cellular cholesterol homeostasis. We examined the effects of oxysterols on the expression of steroidogenic acute regulatory protein (StAR), which increases the delivery of cholesterol...