T Daniel Andrews
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Explore the profile of T Daniel Andrews including associated specialties, affiliations and a list of published articles.
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33
Citations
6104
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Recent Articles
1.
May M, Chuah A, Lehmann N, Goodall L, Cho V, Andrews T
Nat Commun
. 2025 Mar;
16(1):2492.
PMID: 40082446
Missense mutations that disrupt protein structural stability are a common pathogenic mechanism in human genetic disease. Here, we quantify potential disruption of protein stability due to amino acid substitution and...
2.
Medhavy A, Athanasopoulos V, Bassett K, He Y, Stanley M, Enosi Tuipulotu D, et al.
Nat Immunol
. 2024 Jul;
25(9):1678-1691.
PMID: 39060650
Whole-exome sequencing of two unrelated kindreds with systemic autoimmune disease featuring antinuclear antibodies with IgG4 elevation uncovered an identical ultrarare heterozygous TNIP1 variant segregating with disease. Mice with the orthologous...
3.
Brown G, Canete P, Wang H, Medhavy A, Bones J, Roco J, et al.
Nature
. 2022 Apr;
605(7909):349-356.
PMID: 35477763
Although circumstantial evidence supports enhanced Toll-like receptor 7 (TLR7) signalling as a mechanism of human systemic autoimmune disease, evidence of lupus-causing TLR7 gene variants is lacking. Here we describe human...
4.
Chuah A, Walters G, Christiadi D, Karpe K, Kennard A, Singer R, et al.
Front Med (Lausanne)
. 2022 Apr;
9:837232.
PMID: 35372378
Background And Objectives: Chronic kidney disease progression to ESKD is associated with a marked increase in mortality and morbidity. Its progression is highly variable and difficult to predict. Methods: This...
5.
McConnell H, Andrews T, Field M
PeerJ
. 2021 Jul;
9:e11774.
PMID: 34316407
Background: Pharmacogenetic variation is important to drug responses through diverse and complex mechanisms. Predictions of the functional impact of missense pharmacogenetic variants primarily rely on the degree of sequence conservation...
6.
Boast B, Miosge L, Kuehn H, Cho V, Athanasopoulos V, McNamara H, et al.
J Immunol
. 2021 Mar;
206(7):1505-1514.
PMID: 33658297
IKZF1 (IKAROS) is essential for normal lymphopoiesis in both humans and mice. Previous mouse models have demonstrated the dual role for IKZF1 in both B and T cell development and...
7.
Hamzeh A, Andrews T, Field M
Methods Mol Biol
. 2021 Feb;
2243:1-25.
PMID: 33606250
Increasingly affordable sequencing technologies are revolutionizing the field of genomic medicine. It is now feasible to interrogate all major classes of variation in an individual across the entire genome for...
8.
Sutton H, Aye R, Idris A, Vistein R, Nduati E, Kai O, et al.
Cell Rep
. 2021 Feb;
34(6):108684.
PMID: 33567273
The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy subjects and...
9.
Kayagaki N, Kornfeld O, Lee B, Stowe I, ORourke K, Li Q, et al.
Nature
. 2021 Jan;
591(7848):131-136.
PMID: 33472215
Plasma membrane rupture (PMR) is the final cataclysmic event in lytic cell death. PMR releases intracellular molecules known as damage-associated molecular patterns (DAMPs) that propagate the inflammatory response. The underlying...
10.
Field M, Burgio G, Chuah A, Al Shekaili J, Hassan B, Al Sukaiti N, et al.
BMC Genomics
. 2019 Jul;
20(Suppl 8):546.
PMID: 31307400
Background: Short-read resequencing of genomes produces abundant information of the genetic variation of individuals. Due to their numerous nature, these variants are rarely exhaustively validated. Furthermore, low levels of undetected...