T D Meek
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Explore the profile of T D Meek including associated specialties, affiliations and a list of published articles.
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34
Citations
872
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Recent Articles
1.
Yang G, Kirkpatrick R, Ho T, Zhang G, Liang P, Johanson K, et al.
Biochemistry
. 2001 Aug;
40(35):10645-54.
PMID: 11524009
The steady-state kinetics of a full-length and truncated form of the type 2 human methionine aminopeptidase (hMetAP2) were analyzed by continuous monitoring of the amide bond cleavage of various peptide...
2.
Hussain I, Powell D, Howlett D, Chapman G, Gilmour L, Murdock P, et al.
Mol Cell Neurosci
. 2000 Nov;
16(5):609-19.
PMID: 11083922
Sequential proteolytic processing of the Amyloid Precursor Protein (APP) by beta- and gamma-secretases generates the 4-kDa amyloid (A beta) peptide, a key component of the amyloid plaques seen in Alzheimer's...
3.
Bossard M, Tomaszek T, Levy M, Ijames C, Huddleston M, Briand J, et al.
Biochemistry
. 2000 Jan;
38(48):15893-902.
PMID: 10625455
The nature of the inhibition of thiol proteases by a new class of mechanism-based inhibitors, 1,5-diacylcarbohydrazides, is described. These potent, time-dependent, active-site spanning inhibitors include compounds that are selective for...
4.
Hussain I, Powell D, Howlett D, Tew D, Meek T, Chapman C, et al.
Mol Cell Neurosci
. 1999 Nov;
14(6):419-27.
PMID: 10656250
The Alzheimer's disease beta-amyloid peptide (Abeta) is produced by excision from the type 1 integral membrane glycoprotein amyloid precursor protein (APP) by the sequential actions of beta- and then gamma-secretases....
5.
Webb M, Meek T
Med Res Rev
. 1997 Jan;
17(1):17-67.
PMID: 8979248
With the advent of the first generation of both selective and nonselective endothelin antagonists being a relatively recent event, the manifold therapeutic potentials of these compounds are only now being...
6.
Thompson S, Murthy K, Zhao B, Winborne E, Green D, Fisher S, et al.
J Med Chem
. 1994 Sep;
37(19):3100-7.
PMID: 7932533
The rational design and synthesis of a highly potent inhibitor of HIV-1 protease have been accomplished. The inhibitor, SB 206343, is based on a model derived from the structure of...
7.
Douglas S, Meek T, Ohlstein E
Trends Pharmacol Sci
. 1994 Sep;
15(9):313-6.
PMID: 7992380
No abstract available.
8.
Meek T, RODRIGUEZ E, Angeles T
Methods Enzymol
. 1994 Jan;
241:127-56.
PMID: 7854175
Despite the current plethora of structural data of HIV-1 protease and the availability of potent inhibitors, whose structures are based in part on the presumed mechanism of action of this...
9.
RODRIGUEZ E, Angeles T, Meek T
Biochemistry
. 1993 Nov;
32(46):12380-5.
PMID: 8241126
We have used 15N kinetic isotope effects of the HIV-1 protease-catalyzed peptidolysis of Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 to characterize the chemical mechanism of this enzyme. In addition, the multiple isotope effects have been...
10.
RODRIGUEZ E, Debouck C, Deckman I, Raushel F, Meek T
Biochemistry
. 1993 Apr;
32(14):3557-63.
PMID: 8466899
HIV-1 protease contains two identical, conformationally mobile loops, known as flaps, which form in part the binding pockets for substrates and inhibitors. We have constructed a site-specific mutant of the...