T C Saido
Overview
Explore the profile of T C Saido including associated specialties, affiliations and a list of published articles.
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Articles
135
Citations
5206
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0
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Recent Articles
1.
Loera-Valencia R, Piras A, Ismail M, Manchanda S, Eyjolfsdottir H, Saido T, et al.
J Intern Med
. 2018 Mar;
284(1):2-36.
PMID: 29582495
Alzheimer's disease (AD) causes dementia in both young and old people affecting more than 40 million people worldwide. The two neuropathological hallmarks of the disease, amyloid beta (Aβ) plaques and...
2.
Nose-Ishibashi K, Watahiki J, Yamada K, Maekawa M, Watanabe A, Yamamoto G, et al.
Neuroscience
. 2014 Jan;
263:257-68.
PMID: 24444829
Mastication is one of the most important oral functions, and the period during which mastication is acquired overlaps with the term of rapid development and maturation of the neural systems....
3.
Koike H, Kouchi Z, Kinouchi T, Maeda T, Sorimachi H, Saido T, et al.
Cytotechnology
. 2008 Nov;
33(1-3):213-9.
PMID: 19002828
Thimet oligopeptidase (TOP) is a thiol- andmetallo-dependent peptidase and has been shown to beone of the beta-secretase candidates. TOPexpressed in COS cells cleaved amyloid precursorprotein (APP) at the beta-secretase site,...
4.
Hama E, Saido T
Med Hypotheses
. 2005 Jun;
65(3):498-500.
PMID: 15921860
We recently demonstrated that amyloid beta peptide (Abeta) is catabolized primarily by a neutral endopeptidase, neprilysin, in the brain and that a neuropeptide, somatostatin (SST), regulates brain Abeta level via...
5.
Wakutani Y, Watanabe K, Adachi Y, Wada-Isoe K, Urakami K, Ninomiya H, et al.
J Neurol Neurosurg Psychiatry
. 2004 Jun;
75(7):1039-42.
PMID: 15201367
Objective: To describe a novel missense mutation, Asp678Asn (D678N), in the amyloid precursor protein (APP) gene in a Japanese pedigree of probable familial Alzheimer's disease (FAD). Subject: The proband was...
6.
Rami A, Volkmann T, Agarwal R, Schoninger S, Nurnberger F, Saido T, et al.
Neurosci Res
. 2003 Nov;
47(4):373-82.
PMID: 14630341
In the CNS, where Ca(2+) overload has been established as a mechanism contributing to neuronal damage associated with excitotoxicity, stroke and ischemia, there is interest in understanding the role of...
7.
Kim J, Han B, Choi W, Eom D, Lee E, Oh T, et al.
J Neurosci Res
. 2001 Dec;
66(6):1074-82.
PMID: 11746439
Etoposide-induced death comprises such nuclear events as the formation of topoisomerase II-DNA cleavable complex and cytosolic events including caspase activation. By first establishing the temporospatial death sequence triggered by etoposide...
8.
Kaneko T, Yamashima T, Tohma Y, Nomura M, Imajoh-Ohmi S, Saido T, et al.
Cancer
. 2001 Dec;
92(10):2662-72.
PMID: 11745202
Background: The purpose of this study is to indicate that oxidative stress may contribute to occurrence of meningiomas. Recently, it was reported that aside from the neurofibromatosis type 2 (NF2)...
9.
Hama E, SHIROTANI K, Masumoto H, Aizawa H, Saido T
J Biochem
. 2001 Dec;
130(6):721-6.
PMID: 11726269
Amyloid beta peptide (Abeta), the pathogenic agent of Alzheimer's disease (AD), is a physiological metabolite constantly anabolized and catabolized in the brain. We previously demonstrated that neprilysin is the major...
10.
Kitazume S, Tachida Y, Oka R, SHIROTANI K, Saido T, Hashimoto Y
Proc Natl Acad Sci U S A
. 2001 Nov;
98(24):13554-9.
PMID: 11698669
The deposition of amyloid beta-peptide (A beta) in the brain is closely associated with the development of Alzheimer's disease. A beta is generated from the amyloid precursor protein (APP) by...