S Tsubuki
Overview
Explore the profile of S Tsubuki including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
1297
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Recent Articles
1.
Iwata N, Tsubuki S, Takaki Y, SHIROTANI K, Lu B, Gerard N, et al.
Science
. 2001 May;
292(5521):1550-2.
PMID: 11375493
Amyloid beta peptide (Abeta), the pathogenic agent of Alzheimer's disease (AD), is a physiological metabolite in the brain. We examined the role of neprilysin, a candidate Abeta-degrading peptidase, in the...
2.
SHIROTANI K, Tsubuki S, Iwata N, Takaki Y, Harigaya W, Maruyama K, et al.
J Biol Chem
. 2001 Mar;
276(24):21895-901.
PMID: 11278416
To identify the amyloid beta peptide (Abeta) 1-42-degrading enzyme whose activity is inhibited by thiorphan and phosphoramidon in vivo, we searched for neprilysin (NEP) homologues and cloned neprilysin-like peptidase (NEPLP)...
3.
Lee K, Ohyama T, Yajima N, Tsubuki S, Yonehara S
J Biol Chem
. 2001 Mar;
276(22):19276-85.
PMID: 11278283
The human serine/threonine kinase, mammalian STE20-like kinase (MST), is considerably homologous to the budding yeast kinases, SPS1 and STE20, throughout their kinase domains. The cellular function and physiological activation mechanism...
4.
Hama E, Watanabe K, Tsubuki S, Kanai Y, Arai H, Aizawa H, et al.
Eur J Neurosci
. 2001 Mar;
13(5):935-48.
PMID: 11264666
The matrix metalloproteinase (MMP) family, comprising more than 20 isoforms, modulates the extracellular milieu by degrading extracellular matrix (ECM) proteins. Because MMP is one of the few groups of proteinases...
5.
Takaki Y, Iwata N, Tsubuki S, Taniguchi S, Toyoshima S, Lu B, et al.
J Biochem
. 2000 Dec;
128(6):897-902.
PMID: 11098130
Amyloid beta peptide (Abeta) is a physiological peptide that is constantly catabolized in the brain. We previously demonstrated that an endopeptidase sensitive to phosphoramidon and thiorphan conducts the initial rate-limiting...
6.
Kubo H, Kawano T, Tsubuki S, Kotani M, Kawasaki H, Kawashima S
Dev Growth Differ
. 2000 Sep;
42(4):419-27.
PMID: 10969742
The egg envelope is a kind of extracellular matrix, which surrounds growing oocytes, ovulated eggs and early embryos. Among the glycoprotein components of the Xenopus laevis egg envelope, gp43/gp41 and...
7.
Iwata N, Tsubuki S, Takaki Y, Watanabe K, Sekiguchi M, Hosoki E, et al.
Nat Med
. 2000 Feb;
6(2):143-50.
PMID: 10655101
Alzheimer amyloid beta-peptide (Abeta) is a physiological peptide constantly anabolized and catabolized under normal conditions. We investigated the mechanism of catabolism by tracing multiple-radiolabeled synthetic peptide injected into rat hippocampus....
8.
Yokota M, Tani E, Tsubuki S, Yamaura I, Nakagaki I, Hori S, et al.
Brain Res
. 1999 Mar;
819(1-2):8-14.
PMID: 10082855
Transient forebrain ischemia induces activation of calpain and proteolysis of a neuronal cytoskeleton, fodrin, in gerbil hippocampus. This phenomenon precedes delayed neuronal death in hippocampal CA1 neurons. We examined effects...
9.
Honda T, Yasutake K, Nihonmatsu N, Mercken M, Takahashi H, Murayama O, et al.
J Neurochem
. 1999 Jan;
72(1):255-61.
PMID: 9886077
Presenilin 1 (PS1) has been identified as a causative gene for most early-onset familial Alzheimer's disease. Biochemical studies revealed that PS1 exists predominantly as two processed fragments in cells and...
10.
Lee K, Murakawa M, Takahashi S, Tsubuki S, Kawashima S, Sakamaki K, et al.
J Biol Chem
. 1998 Jul;
273(30):19160-6.
PMID: 9668102
We purified a protein of 32 kDa from human thymoma HPB-ALL cells that was co-purified with a catalytic fragment of MST (mammalian STE-20-like), a kinase of the STE20 family, which...