T C Dale
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Explore the profile of T C Dale including associated specialties, affiliations and a list of published articles.
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23
Citations
1562
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Recent Articles
1.
Jarde T, Evans R, McQuillan K, Parry L, Feng G, Alvares B, et al.
Oncogene
. 2012 Apr;
32(7):883-93.
PMID: 22469981
Although significant progress has been made in understanding the importance of Wnt signaling in the initiation of colorectal cancer, less is known about responses that accompany the reversal of oncogenic...
2.
Forde J, Dale T
Cell Mol Life Sci
. 2007 May;
64(15):1930-44.
PMID: 17530463
The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified as a key regulator of insulin-dependent glycogen synthesis. GSK-3 was subsequently shown to function in a wide range of cellular...
3.
Smalley M, Dale T
J Mammary Gland Biol Neoplasia
. 2001 Jul;
6(1):37-52.
PMID: 11467451
Wnt expression patterns during mammary development support a role for Wnts in breast development and in mammary epithelial responses to systemic hormones. The deregulation of Wnt signaling also plays a...
4.
Dajani R, Fraser E, Roe S, Young N, Good V, Dale T, et al.
Cell
. 2001 Jul;
105(6):721-32.
PMID: 11440715
Glycogen synthase kinase 3 beta (GSK3 beta) plays a key role in insulin and Wnt signaling, phosphorylating downstream targets by default, and becoming inhibited following the extracellular signaling event. The...
5.
Heisenberg C, Houart C, Take-Uchi M, Rauch G, Young N, Coutinho P, et al.
Genes Dev
. 2001 Jun;
15(11):1427-34.
PMID: 11390362
Zebrafish embryos homozygous for the masterblind (mbl) mutation exhibit a striking phenotype in which the eyes and telencephalon are reduced or absent and diencephalic fates expand to the front of...
6.
Webster M, Rozycka M, Sara E, Davis E, Smalley M, Young N, et al.
Genes Chromosomes Cancer
. 2000 Jun;
28(4):443-53.
PMID: 10862053
Axin is a recently discovered component of a multiprotein complex containing APC, beta-catenin, GSK3, and PP2A, which functions in the degradation of the beta-catenin protein. As part of WNT signal...
7.
Naylor S, Smalley M, Robertson D, Gusterson B, Edwards P, Dale T
J Cell Sci
. 2000 May;
113 ( Pt 12):2129-38.
PMID: 10825286
Several Wnt genes are expressed in the postnatal mouse mammary gland and are thought to be involved in mammary gland development. Ectopic expression of Wnt-1, which is not normally expressed...
8.
Smalley M, Dale T
Cancer Metastasis Rev
. 2000 Mar;
18(2):215-30.
PMID: 10728985
Wnt signalling is involved in a variety of mammalian developmental processes, including cell proliferation, differentiation and epithelial-mesenchymal interactions, through which they contribute to the development of tissues and organs such...
9.
Smalley M, Sara E, PATERSON H, Naylor S, Cook D, Jayatilake H, et al.
EMBO J
. 1999 May;
18(10):2823-35.
PMID: 10329628
Axin promotes the phosphorylation of beta-catenin by GSK-3beta, leading to beta-catenin degradation. Wnt signals interfere with beta-catenin turnover, resulting in enhanced transcription of target genes through the increased formation of...
10.
Dale T
Biochem J
. 1998 Feb;
329 ( Pt 2):209-23.
PMID: 9425102
The Wnt genes encode a large family of secreted polypeptides that mediate cell-cell communication in diverse developmental processes. The loss or inappropriate activation of Wnt expression has been shown to...