T B Shea
Overview
Explore the profile of T B Shea including associated specialties, affiliations and a list of published articles.
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Articles
123
Citations
1144
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Recent Articles
21.
Ekinci F, Linsley M, Shea T
Brain Res Mol Brain Res
. 2000 Apr;
76(2):389-95.
PMID: 10762716
Beta-amyloid (betaA) toxicity in culture is accompanied by multiple events culminating in apoptosis. Calcium influx may represent the initial event, since calcium chelation prevents all subsequent events, while subsequent events...
22.
Yabe J, Jung C, Chan W, Shea T
Cell Motil Cytoskeleton
. 2000 Apr;
45(4):249-62.
PMID: 10744858
Recent studies demonstrate co-localization of kinesin with neurofilament (NF) subunits in culture and suggest that kinesin participates in NF subunit distribution. We sought to determine whether kinesin was also associated...
23.
Jung C, Yabe J, Shea T
Brain Res
. 2000 Mar;
856(1-2):12-9.
PMID: 10677606
We probed the relationship of NF axonal transport of neurofilaments (NFs) to their phosphorylation state by comparing these parameters in two closely-aged groups of young adult mice - 2 and...
24.
Ma D, Himes B, Shea T, Fischer I
J Neurosci
. 2000 Mar;
20(6):2112-20.
PMID: 10704485
Cytoskeletal proteins are axonally transported with slow components a and b (SCa and SCb). In peripheral nerves, the transport velocity of SCa, which includes neurofilaments and tubulin, is 1-2 mm/d,...
25.
Ekinci F, Shea T
Brain Res
. 2000 Jan;
850(1-2):207-16.
PMID: 10629766
Protein kinase C (PKC) is reversibly activated at the plasma membrane by the generation of diacylglycerol (DAG) coupled with the release of Ca2+ from intracellular stores. PKC is also irreversibly...
26.
Yabe J, Pimenta A, Shea T
J Cell Sci
. 1999 Oct;
112 ( Pt 21):3799-814.
PMID: 10523515
We examined cytoskeleton-associated forms of NF proteins during axonal neuritogenesis in cultured dorsal root ganglion (DRG) neurons and NB2a/d1 neuroblastoma. In addition to filamentous immunoreactivity, we observed punctate NF immunoreactivity...
27.
Ekinci F, Malik K, Shea T
J Biol Chem
. 1999 Oct;
274(42):30322-7.
PMID: 10514528
Neuronal degeneration in Alzheimer's disease (AD) has been variously attributed to increases in cytosolic calcium, reactive oxygen species, and phosphorylated forms of the microtubule-associated protein tau. beta-Amyloid (betaA), which accumulates...
28.
Shea T, Beermann M
Cell Motil Cytoskeleton
. 1999 Jul;
43(4):322-33.
PMID: 10423273
We examined the localization and role of alpha-IN vs. other neuronal intermediate filaments before and during differentiation. Vimentin but not alpha-IN localized within filopodia-like neurites of undifferentiated cells. During differentiation,...
29.
Shea T
Brain Res Bull
. 1999 May;
48(3):255-61.
PMID: 10229332
This study examined the distribution of labile and stable microtubules (MTs) during axonal neurite elaboration in NB2a/d1 cells using immunocytochemical markers of unmodified (tyrosinated; Tyr), modified (detyrosinated [Glu] and acetylated...
30.
Jung C, Shea T
Cell Motil Cytoskeleton
. 1999 Mar;
42(3):230-40.
PMID: 10098936
Axonal transport of neurofilament (NFs) is considered to be regulated by phosphorylation. While existing evidence for this hypothesis is compelling, supportive studies have been largely restricted to correlative evidence and/or...