T A Linkhart
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Explore the profile of T A Linkhart including associated specialties, affiliations and a list of published articles.
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58
Citations
924
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Recent Articles
1.
Miyakoshi N, Kasukawa Y, Linkhart T, Baylink D, Mohan S
Endocrinology
. 2001 Sep;
142(10):4349-56.
PMID: 11564695
Although it has been established that PTH exerts potent anabolic effects on bone in animals and humans, the mechanism of PTH action on bone remains controversial. Based on the previous...
2.
Dailly Y, Zhou Y, Linkhart T, Baylink D, Strong D
Biochim Biophys Acta
. 2001 Mar;
1518(1-2):145-51.
PMID: 11267670
The 1.7 kb human insulin-like growth factor binding protein (IGFBP)-6 gene 5'-flanking region was sequenced and found to have promoter activity in human osteoblasts. The sequence contains four clustered transcription...
3.
Miyakoshi N, RICHMAN C, Kasukawa Y, Linkhart T, Baylink D, Mohan S
J Clin Invest
. 2001 Jan;
107(1):73-81.
PMID: 11134182
Recent studies support the concept that IGF-binding protein-5 (IGFBP-5) stimulates bone formation, at least in part, via IGF-independent mechanisms. To evaluate this hypothesis further, we evaluated in vitro and in...
4.
Kodama Y, Miyakoshi N, Linkhart T, Wergedal J, Srivastava A, Beamer W, et al.
Bone
. 2000 Aug;
27(3):445-52.
PMID: 10962358
As an adjunct to our efforts to identify the genes that determine peak bone density, we examined phenotypic differences between two inbred strains of mice, C3H/HeJ (C3H) and C57BL/6J (B6),...
5.
Boonyaratanakornkit V, Strong D, Mohan S, Baylink D, Beck C, Linkhart T
J Biol Chem
. 1999 Sep;
274(37):26431-8.
PMID: 10473602
Insulin-like growth factor-binding protein-5 (IGFBP-5) is produced by osteoblasts and potentiates insulin-like growth factor mitogenic stimulation in osteoblast cell cultures. Progesterone (PG) increased IGFBP-5 expression in normal human osteoblasts and...
6.
Linkhart T, Linkhart S, Kodama Y, Farley J, Dimai H, Wright K, et al.
J Bone Miner Res
. 1999 Jan;
14(1):39-46.
PMID: 9893064
For the purpose of identifying genes that affect bone volume, we previously identified two inbred mouse strains (C57BL/6J and C3H/HeJ) with large differences in femoral bone density and medullary cavity...
7.
Dimai H, Linkhart T, Linkhart S, Donahue L, Beamer W, Rosen C, et al.
Bone
. 1998 Mar;
22(3):211-6.
PMID: 9514213
Previous studies have shown that C3H/HeJ (C3H) mice have higher peak bone density than C57BL/6J (B6) mice, at least in part because of differences in rates of bone resorption. The...
8.
Malpe R, Baylink D, Linkhart T, Wergedal J, Mohan S
J Bone Miner Res
. 1997 Mar;
12(3):423-30.
PMID: 9076585
The skeleton in its function of affording strength and support to the body is subject to differential mechanical loading which has been implicated to mediate some of its effects on...
9.
Linkhart T, Mohan S, Baylink D
Bone
. 1996 Jul;
19(1 Suppl):1S-12S.
PMID: 8830994
Current research is reviewed regarding the actions of three growth factor systems on bone formation: insulin-like growth factors (IGFs), transforming growth factor-betas (TGF betas), and bone morphogenetic proteins (BMPs). Each...
10.
Srinivasan N, Edwall D, Linkhart T, Baylink D, Mohan S
J Endocrinol
. 1996 May;
149(2):297-303.
PMID: 8708541
The PC-3 human prostatic carcinoma cell line has been extensively used as a model for studies on the regulation of prostate tumor cell proliferation. Because of the importance of IGF-binding...