T A Keinanen
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Explore the profile of T A Keinanen including associated specialties, affiliations and a list of published articles.
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16
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76
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Recent Articles
1.
Khomutov M, Keinanen T, Hyvonen M, Weisell J, Vepsalainen J, Alhonen L, et al.
Bioorg Khim
. 2016 Jan;
41(5):612-8.
PMID: 26762100
Earlier unknown enantiomerically pure (R)- and (S)-1,8-diamino-3-methyl-4-azaoctane's (3-MeSpd's) were synthesized with high overall yields and optical purity starting from commercially available R- and S-isomers of N-Boc-2-aminopropanol-1. Application of R- and...
2.
Keinanen T, Khivonen T, Vepsalajnen I, Alhonen L, Homutov A, Ianne I
Bioorg Khim
. 2015 Apr;
40(2):170-7.
PMID: 25895336
Convenient two-step synthesis of conjugates of HS-CoA and D-pantetheine with aminooxy analogues of Spm, Spd and Put was suggested. The use of acetone linker provided target conjugates with quantitative yields....
3.
Khomutov M, Weisell J, Hyvonen M, Keinanen T, Vepsalainen J, Alhonen L, et al.
Biochemistry (Mosc)
. 2014 Feb;
78(13):1431-46.
PMID: 24490733
The biogenic polyamines spermine, spermidine, and their precursor putrescine are present in micro-to-millimolar concentrations in all cell types and are vitally important for their normal growth. High intracellular content of...
4.
Khomutov M, Khivonen M, Simonian A, Vepsalainen I, Alkhonen L, Kochetkov S, et al.
Bioorg Khim
. 2011 Jul;
37(2):253-8.
PMID: 21721258
Earlier unknown 1,8-diamino-3-methyl-4-azaoctane (gamma-MeSpd) was synthesized. The analogue was not a substrate of ether spermine/spermidine N1-acetyltransferase, or spermine synthase, but was capable to support the growth of DU145 cells with...
5.
Hyvonen M, Sinervirta R, Keinanen T, Fashe T, Grigorenko N, Khomutov A, et al.
Pancreatology
. 2010 May;
10(2-3):208-21.
PMID: 20453551
Background/aims: Polyamines are ubiquitous organic cations essential for cellular proliferation and tissue integrity. We have previously shown that pancreatic polyamine depletion in rats overexpressing the catabolic enzyme, spermidine/spermine N(1)-acetyltransferase (SSAT),...
6.
Khomutov A, Keinanen T, Grigorenko N, Hyvonen M, Uimari A, Pietila M, et al.
Mol Biol (Mosk)
. 2009 May;
43(2):274-85.
PMID: 19425496
Biogenic amines spermine and spermidine are essential factors of cellular growth. Polyamine analogues are widely used to investigate and to regulate the enzymes of polyamine metabolism and functions of spermine...
7.
Merentie M, Uimari A, Pietila M, Sinervirta R, Keinanen T, Vepsalainen J, et al.
Amino Acids
. 2007 Apr;
33(2):323-30.
PMID: 17410333
The markers of oxidative stress and inflammation were studied in acute pancreatitis in transgenic rats exhibiting activated polyamine catabolism. In addition, the effect of bismethylspermine (Me(2)Spm) pretreatment, preventing pancreatitis in...
8.
Hyvonen M, Merentie M, Uimari A, Keinanen T, Janne J, Alhonen L
Biochem Soc Trans
. 2007 Mar;
35(Pt 2):326-30.
PMID: 17371271
Acute pancreatitis is an autodigestive disease, in which the pancreatic tissue is damaged by the digestive enzymes produced by the acinar cells. Among the tissues in the mammalian body, pancreas...
9.
Khomutov A, Simonian A, Vespalainen J, Keinanen T, Alhonen L, Janne J
Bioorg Khim
. 2005 May;
31(2):206-12.
PMID: 15889796
A new isosteric charge-deficient spermine analogue, 1,12-diamino-4,9-diaza-5-oxadodecan, and O-(7-amino-4-azaheptyl)oxime of 3-aminopropanal, a stable analogue of the Schiff base intermediate in the enzymatic oxidation of spermine, were synthesized. The possible use...
10.
Grigorenko N, Vepsalainen J, Jarvinen A, Keinanen T, Alhonen L, Janne J, et al.
Bioorg Khim
. 2005 May;
31(2):200-5.
PMID: 15889795
alpha-Methylspermine and alpha,alpha'-dimethylspermine were synthesized in high overall yields starting from N-(benzyloxycarbonyl)-3-aminobutanol in order to study polyamine biochemistry in vitro and in vivo.