A R Khomutov
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Explore the profile of A R Khomutov including associated specialties, affiliations and a list of published articles.
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42
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142
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Recent Articles
1.
Bakunova A, Matyuta I, Nikolaeva A, Boyko K, Khomutov A, Bezsudnova E, et al.
Acta Naturae
. 2024 Nov;
16(3):18-24.
PMID: 39539521
Pyridoxal 5'-phosphate-dependent enzymes play a crucial role in nitrogen metabolism. Carbonyl compounds, such as O-substituted hydroxylamines, stand out among numerous specific inhibitors of these enzymes, including those of practical importance,...
2.
Filonov V, Khomutov M, Sergeev A, Khandazhinskaya A, Kochetkov S, Gromova E, et al.
Mol Biol (Mosk)
. 2023 Aug;
57(4):717-725.
PMID: 37528794
Enzymatic methyltransferase reactions are of crucial importance for cell metabolism. S-Adenosyl-L-methionine (AdoMet) is a main donor of the methyl group. DNA, RNA, proteins, and low-molecular-weight compounds are substrates of methyltransferases....
3.
Dunston T, Khomutov M, Gabelli S, Stewart T, Foley J, Kochetkov S, et al.
Acta Naturae
. 2020 Nov;
12(3):140-144.
PMID: 33173604
Homeostasis of the biogenic polyamines spermine (Spm) and spermidine (Spd), present in μM-mM concentrations in all eukaryotic cells, is precisely regulated by coordinated activities of the enzymes of polyamine synthesis,...
4.
Khomutov M, Keinanen T, Hyvonen M, Weisell J, Vepsalainen J, Alhonen L, et al.
Bioorg Khim
. 2016 Jan;
41(5):612-8.
PMID: 26762100
Earlier unknown enantiomerically pure (R)- and (S)-1,8-diamino-3-methyl-4-azaoctane's (3-MeSpd's) were synthesized with high overall yields and optical purity starting from commercially available R- and S-isomers of N-Boc-2-aminopropanol-1. Application of R- and...
5.
Khomutov M, Weisell J, Hyvonen M, Keinanen T, Vepsalainen J, Alhonen L, et al.
Biochemistry (Mosc)
. 2014 Feb;
78(13):1431-46.
PMID: 24490733
The biogenic polyamines spermine, spermidine, and their precursor putrescine are present in micro-to-millimolar concentrations in all cell types and are vitally important for their normal growth. High intracellular content of...
6.
Korovina A, Tunitskaya V, Khomutov M, Simonian A, Khomutov A, Ivanov A, et al.
Biochemistry (Mosc)
. 2012 Nov;
77(10):1172-80.
PMID: 23157297
Influence of the biogenic polyamines spermine, spermidine, and putrescine as well as their derivatives on the replication enzymes of hepatitis C virus (HCV) was investigated. It was found that spermine...
7.
Tunitskaya V, Khomutov A, Kochetkov S, Kotovskaya S, Charushin V
Acta Naturae
. 2012 Jun;
3(4):94-9.
PMID: 22649708
Fluoroquinolones are an important class of modern and efficient antibacterial drugs with a broad spectrum of activity. Levofloxacin (the optically active form of ofloxacin) is one of the most promising...
8.
Hyvonen M, Sinervirta R, Keinanen T, Fashe T, Grigorenko N, Khomutov A, et al.
Pancreatology
. 2010 May;
10(2-3):208-21.
PMID: 20453551
Background/aims: Polyamines are ubiquitous organic cations essential for cellular proliferation and tissue integrity. We have previously shown that pancreatic polyamine depletion in rats overexpressing the catabolic enzyme, spermidine/spermine N(1)-acetyltransferase (SSAT),...
9.
Khomutov A, Keinanen T, Grigorenko N, Hyvonen M, Uimari A, Pietila M, et al.
Mol Biol (Mosk)
. 2009 May;
43(2):274-85.
PMID: 19425496
Biogenic amines spermine and spermidine are essential factors of cellular growth. Polyamine analogues are widely used to investigate and to regulate the enzymes of polyamine metabolism and functions of spermine...
10.
Grillo M, Battaglia V, Colombatto S, Rossi C, Simonian A, Salvi M, et al.
Biochem Soc Trans
. 2007 Mar;
35(Pt 2):401-4.
PMID: 17371286
The charge of the agmatine analogues AO-Agm [N-(3-aminooxypropyl)guanidine], GAPA [N-(3-aminopropoxy)guanidine] and NGPG [N-(3-guanidinopropoxy)guanidine] is deficient as compared with that of agmatine and they are thus able to inhibit agmatine transport...