[New Syntheses of Alpha-methyl- and Alpha,alpha'-dimethylspermine]

Overview

Journal Bioorg Khim

Specialties Biochemistry
Molecular Biology

Date 2005 May 14

PMID 15889795

Citations 2

Authors

N A Grigorenko

J Vepsalainen

A Jarvinen

T A Keinanen

L Alhonen

J Janne

A R Khomutov

Affiliations

Soon will be listed here.

Abstract

alpha-Methylspermine and alpha,alpha'-dimethylspermine were synthesized in high overall yields starting from N-(benzyloxycarbonyl)-3-aminobutanol in order to study polyamine biochemistry in vitro and in vivo.

Citing Articles

Polyamine-regulated unproductive splicing and translation of spermidine/spermine N1-acetyltransferase.

Hyvonen M, Uimari A, Keinanen T, Heikkinen S, Pellinen R, Wahlfors T RNA. 2006; 12(8):1569-82.

PMID: 16809818 PMC: 1524884. DOI: 10.1261/rna.39806.

activated polyamine catabolism in acute pancreatitis: alpha-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality.

Hyvonen M, Herzig K, Sinervirta R, Albrecht E, Nordback I, Sand J Am J Pathol. 2006; 168(1):115-22.

PMID: 16400014 PMC: 1592678. DOI: 10.2353/ajpath.2006.050518.