Szymon Klossowski
Overview
Explore the profile of Szymon Klossowski including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
15
Citations
310
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Rogawski D, Deng J, Li H, Miao H, Borkin D, Purohit T, et al.
Nat Commun
. 2021 May;
12(1):2792.
PMID: 33990599
ASH1L histone methyltransferase plays a crucial role in the pathogenesis of different diseases, including acute leukemia. While ASH1L represents an attractive drug target, developing ASH1L inhibitors is challenging, as the...
2.
Miao H, Kim E, Chen D, Purohit T, Kempinska K, Ropa J, et al.
Blood
. 2020 Dec;
136(25):2958-2963.
PMID: 33331926
No abstract available.
3.
Klossowski S, Miao H, Kempinska K, Wu T, Purohit T, Kim E, et al.
J Clin Invest
. 2019 Dec;
130(2):981-997.
PMID: 31855575
The protein-protein interaction between menin and mixed lineage leukemia 1 (MLL1) plays a critical role in acute leukemias with translocations of the MLL1 gene or with mutations in the nucleophosmin...
4.
Borkin D, Klossowski S, Pollock J, Miao H, Linhares B, Kempinska K, et al.
J Med Chem
. 2018 May;
61(11):4832-4850.
PMID: 29738674
The protein-protein interaction between menin and mixed-lineage leukemia 1 (MLL1) plays an important role in development of acute leukemia with translocations of the MLL1 gene and in solid tumors. Here,...
5.
Svoboda L, Teh S, Sud S, Kerk S, Zebolsky A, Treichel S, et al.
J Pathol
. 2018 Apr;
245(3):324-336.
PMID: 29672864
Developmental transcription programs are epigenetically regulated by multi-protein complexes, including the menin- and MLL-containing trithorax (TrxG) complexes, which promote gene transcription by depositing the H3K4me3 activating mark at target gene...
6.
Jedwabny W, Klossowski S, Purohit T, Cierpicki T, Grembecka J, Dyguda-Kazimierowicz E
Medchemcomm
. 2018 Feb;
8(12):2216-2227.
PMID: 29456828
Development and binding affinity predictions of inhibitors targeting protein-protein interactions (PPI) still represent a major challenge in drug discovery efforts. This work reports application of a predictive non-empirical model of...
7.
Kempinska K, Malik B, Borkin D, Klossowski S, Shukla S, Miao H, et al.
Mol Cancer Ther
. 2017 Nov;
17(1):26-38.
PMID: 29142068
Hepatocellular carcinoma (HCC) accounts for approximately 85% of malignant liver tumors and results in 600,000 deaths each year, emphasizing the need for new therapies. Upregulation of menin was reported in...
8.
Zadlo-Dobrowolska A, Klossowski S, Koszelewski D, Paprocki D, Ostaszewski R
Chemistry
. 2016 Oct;
22(46):16684-16689.
PMID: 27689846
The application of the Ugi reaction to the construction of new peptide scaffolds is an important goal of organic chemistry. To date, there are no examples of the Ugi reaction...
9.
Carpenter C, Sorenson R, Jin Y, Klossowski S, Cierpicki T, Gnegy M, et al.
Bioorg Med Chem
. 2016 Sep;
24(21):5495-5504.
PMID: 27647375
The clinical selective estrogen receptor modulator tamoxifen is also a modest inhibitor of protein kinase C, a target implicated in several untreatable brain diseases such as amphetamine abuse. This inhibition...
10.
Trzeciecka A, Klossowski S, Bajor M, Zagozdzon R, Gaj P, Muchowicz A, et al.
Oncotarget
. 2015 Dec;
7(2):1717-31.
PMID: 26636537
Burkitt lymphoma is a fast-growing tumor derived from germinal center B cells. It is mainly treated with aggressive chemotherapy, therefore novel therapeutic approaches are needed due to treatment toxicity and...