Symen Ligthart
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Explore the profile of Symen Ligthart including associated specialties, affiliations and a list of published articles.
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50
Citations
4265
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Recent Articles
1.
Hahn J, Temprano-Sagrera G, Hasbani N, Ligthart S, Dehghan A, Wolberg A, et al.
J Thromb Haemost
. 2024 Sep;
22(12):3448-3459.
PMID: 39299614
Background: Fibrinogen and C-reactive protein (CRP) play an important role in inflammatory pathways and share multiple genetic loci reported in previously published genome-wide association studies (GWAS), highlighting their common genetic...
2.
Suzuki K, Hatzikotoulas K, Southam L, Taylor H, Yin X, Lorenz K, et al.
Nature
. 2024 Feb;
627(8003):347-357.
PMID: 38374256
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution...
3.
Peleman C, Van Coillie S, Ligthart S, Choi S, De Waele J, Depuydt P, et al.
Cell Death Differ
. 2023 Aug;
30(9):2066-2077.
PMID: 37582864
Critical COVID-19 patients admitted to the intensive care unit (ICU) frequently suffer from severe multiple organ dysfunction with underlying widespread cell death. Ferroptosis and pyroptosis are two detrimental forms of...
4.
Said S, Pazoki R, Karhunen V, Vosa U, Ligthart S, Bodinier B, et al.
Nat Commun
. 2022 Jul;
13(1):3865.
PMID: 35790731
No abstract available.
5.
Mahajan A, Spracklen C, Zhang W, Ng M, Petty L, Kitajima H, et al.
Nat Genet
. 2022 May;
54(5):560-572.
PMID: 35551307
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis...
6.
Said S, Pazoki R, Karhunen V, Vosa U, Ligthart S, Bodinier B, et al.
Nat Commun
. 2022 Apr;
13(1):2198.
PMID: 35459240
Chronic low-grade inflammation is linked to a multitude of chronic diseases. We report the largest genome-wide association study (GWAS) on C-reactive protein (CRP), a marker of systemic inflammation, in UK...
7.
Roa Duenas O, van der Burgh A, Ittermann T, Ligthart S, Ikram M, Peeters R, et al.
J Clin Endocrinol Metab
. 2022 Feb;
107(6):1789-1798.
PMID: 35137143
Context: Thyroid hormones are important regulators of glucose metabolism, and studies investigating the association between thyroid function and type 2 diabetes incidence have shown conflicting results. Objective: We aimed to...
8.
Hasbani N, Ligthart S, Brown M, Heath A, Bebo A, Ashley K, et al.
Circulation
. 2022 Jan;
145(11):808-818.
PMID: 35094551
Background: Understanding the effect of lifestyle and genetic risk on the lifetime risk of coronary heart disease (CHD) is important to improving public health initiatives. Our objective was to quantify...
9.
Ligthart S, Hasbani N, Ahmadizar F, van Herpt T, Leening M, Uitterlinden A, et al.
Diabet Med
. 2021 Jul;
38(10):e14639.
PMID: 34245042
Aims: Both lifestyle factors and genetic background contribute to the development of type 2 diabetes. Estimation of the lifetime risk of diabetes based on genetic information has not been presented,...
10.
Portilla-Fernandez E, Hwang S, Wilson R, Maddock J, Hill W, Teumer A, et al.
Eur J Epidemiol
. 2021 Jun;
36(11):1143-1155.
PMID: 34091768
Common carotid intima-media thickness (cIMT) is an index of subclinical atherosclerosis that is associated with ischemic stroke and coronary artery disease (CAD). We undertook a cross-sectional epigenome-wide association study (EWAS)...