Sweta B Patel
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Explore the profile of Sweta B Patel including associated specialties, affiliations and a list of published articles.
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18
Citations
164
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Recent Articles
1.
Kuznetsova V, Krishnan V, Costa A, Ren X, Ricketts T, Patel S, et al.
Blood Adv
. 2024 Nov;
9(4):759-773.
PMID: 39571169
Natural killer (NK) cells play an integral role in immunosurveillance against myeloid malignancies, with their mature phenotype and abundance linked to prolonged treatment-free remission in chronic myeloid leukemia (CML). However,...
2.
Patel S, Moskop D, Jordan C, Pietras E
Semin Hematol
. 2024 Oct;
61(6):409-419.
PMID: 39472255
In work spanning several decades, extensive studies have focused on the properties of malignant stem cells that drive the pathogenesis of acute myeloid leukemia (AML). However, relatively little attention has...
3.
Mills T, Kain B, Burchill M, Danis E, Lucas E, Culp-Hill R, et al.
Cell Stem Cell
. 2024 Oct;
31(11):1630-1649.e8.
PMID: 39413777
Here, we investigate the contribution of long-term hematopoietic stem cells (HSCs) to trained immunity (TI) in the setting of chronic autoimmune disease. Using a mouse model of systemic lupus erythematosus...
4.
Sheth A, Althoff M, Tolison H, Engel K, Amaya M, Krug A, et al.
Cancer Discov
. 2024 May;
14(10):1922-1939.
PMID: 38787341
Acute myeloid leukemia stem cells (LSCs) are uniquely reliant on oxidative phosphorylation (OXPHOS) for survival. Moreover, maintenance of OXPHOS is dependent on BCL-2, creating a therapeutic opportunity to target LSCs...
5.
Sheth A, Engel K, Tolison H, Althoff M, Amaya M, Krug A, et al.
bioRxiv
. 2023 Oct;
PMID: 37873284
We previously reported that acute myeloid leukemia stem cells (LSCs) are uniquely reliant on oxidative phosphorylation (OXPHOS) for survival. Moreover, maintenance of OXPHOS is dependent on BCL2, creating a therapeutic...
6.
Pei S, Shelton I, Gillen A, Stevens B, Gasparetto M, Wang Y, et al.
Cancer Discov
. 2023 Jun;
13(9):2032-2049.
PMID: 37358260
Significance: These studies identify and characterize a new type of human acute myeloid LSC that is responsible for monocytic disease progression in patients with AML treated with venetoclax-based regimens. Our...
7.
Chung J, Ma Y, Zhang D, Bickerton H, Stokes E, Patel S, et al.
iScience
. 2023 Apr;
26(4):106439.
PMID: 37020962
Pancreatic β-cell mass expands during pregnancy and regresses in the postpartum period in conjunction with dynamic metabolic demands on maternal glucose homeostasis. To understand transcriptional changes driving these adaptations in...
8.
Powers C, Sternberg M, Patel S, Pfeiffer C, Storandt R, Schleicher R
J Appl Lab Med
. 2023 Jan;
8(2):272-284.
PMID: 36592081
Background: We compared serum vitamin C (VIC) status of the adult (≥20 y) US population in the National Health and Nutrition Examination Survey (NHANES) 2017-2018 with combined data from 2003-2004...
9.
Patel S, Kuznetsova V, Matkins V, Franceski A, Bassal M, Welner R
Exp Hematol
. 2022 Sep;
115:1-13.
PMID: 36115580
Despite decades of research, standard therapies remain ineffective for most leukemias, pushing toward an essential unmet need for targeted drug screens. Moreover, preclinical drug testing is an important consideration for...
10.
Patel S, Nemkov T, DAlessandro A, Welner R
Front Oncol
. 2022 Jun;
12:846149.
PMID: 35756656
Therapeutic targeting of leukemic stem cells is widely studied to control leukemia. An emerging approach gaining popularity is altering metabolism as a potential therapeutic opportunity. Studies have been carried out...