Susan P Fosmire
Overview
Explore the profile of Susan P Fosmire including associated specialties, affiliations and a list of published articles.
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13
Citations
422
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Recent Articles
1.
Rabe J, Gardner L, Hunter R, Fonseca J, Dougan J, Gearheart C, et al.
Cancer Res
. 2019 May;
79(14):3702-3713.
PMID: 31142509
Exploitation of the immune system has emerged as an important therapeutic strategy for acute lymphoblastic leukemia (ALL). However, the mechanisms of immune evasion during leukemia progression remain poorly understood. We...
2.
Garcia T, Fosmire S, Porter C
Leuk Res
. 2017 Nov;
64:30-33.
PMID: 29175378
Inhibition of WEE1 is emerging as a promising chemosensitization strategy in many cancers including acute leukemia. Our lab and others have demonstrated that a small-molecule inhibitor of WEE1, AZD1775, sensitizes...
3.
Garcia T, Snedeker J, Baturin D, Gardner L, Fosmire S, Zhou C, et al.
Mol Cancer Ther
. 2017 Jun;
16(10):2058-2068.
PMID: 28655785
Although some patients with acute leukemia have good prognoses, the prognosis of adult and pediatric patients who relapse or cannot tolerate standard chemotherapy is poor. Inhibition of WEE1 with AZD1775...
4.
Maycotte P, Gearheart C, Barnard R, Aryal S, Mulcahy Levy J, Fosmire S, et al.
Cancer Res
. 2014 Mar;
74(9):2579-90.
PMID: 24590058
Autophagy is a protein and organelle degradation pathway that is involved in diverse diseases, including cancer. Recent evidence suggests that autophagy is a cell survival mechanism in tumor cells and...
5.
van Linden A, Baturin D, Ford J, Fosmire S, Gardner L, Korch C, et al.
Mol Cancer Ther
. 2013 Oct;
12(12):2675-84.
PMID: 24121103
Inhibition of Wee1 is emerging as a novel therapeutic strategy for cancer, and some data suggest that cells with dysfunctional p53 are more sensitive to Wee1 inhibition combined with conventional...
6.
Tamburini B, Phang T, Fosmire S, Scott M, Trapp S, Duckett M, et al.
BMC Cancer
. 2010 Nov;
10:619.
PMID: 21062482
Background: The etiology of hemangiosarcoma remains incompletely understood. Its common occurrence in dogs suggests predisposing factors favor its development in this species. These factors could represent a constellation of heritable...
7.
Oloris S, Frazer-Abel A, Jubala C, Fosmire S, Helm K, Robinson S, et al.
Toxicol Appl Pharmacol
. 2009 Nov;
242(3):299-309.
PMID: 19896492
The capacity of nicotine to affect the behavior of non-neuronal cells through neuronal nicotinic acetylcholine receptors (nAChRs) has been the subject of considerable recent attention. Previously, we showed that exposure...
8.
Thomas R, Wang H, Tsai P, Langford C, Fosmire S, Jubala C, et al.
Chromosome Res
. 2009 Apr;
17(3):365-377.
PMID: 19337847
Recurrent chromosomal aberrations in solid tumors can reveal the genetic pathways involved in the evolution of a malignancy and in some cases predict biological behavior. However, the role of individual...
9.
Lin P, Fosmire S, Park S, Park J, Baksh S, Modiano J, et al.
Mol Cancer
. 2007 Feb;
6:16.
PMID: 17300726
Background: The PTEN (Phosphatase and Tensin homolog deleted on chromosome Ten) tumor suppressor gene is frequently mutated or deleted in a wide variety of solid tumors, and these cancers are...
10.
Thomas R, Scott A, Langford C, Fosmire S, Jubala C, Lorentzen T, et al.
Genome Res
. 2005 Dec;
15(12):1831-7.
PMID: 16339382
Recognition of the domestic dog as a model for the comparative study of human genetic traits has led to major advances in canine genomics. The pathophysiological similarities shared between many...