Susan K Amundsen
Overview
Explore the profile of Susan K Amundsen including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
248
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0
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Recent Articles
1.
Amundsen S, Smith G
J Mol Biol
. 2024 Feb;
436(6):168482.
PMID: 38331210
Repair of broken DNA is essential for life; the reactions involved can also promote genetic recombination to aid evolution. In Escherichia coli, RecBCD enzyme is required for the major pathway...
2.
Amundsen S, Smith G
Microbiol Mol Biol Rev
. 2023 Dec;
87(4):e0004123.
PMID: 38047637
SUMMARYRecBCD enzyme is a multi-functional protein that initiates the major pathway of homologous genetic recombination and DNA double-strand break repair in . It is also required for high cell viability...
3.
Amundsen S, Richardson A, Ha K, Smith G
Genetics
. 2022 Dec;
223(3).
PMID: 36521180
Escherichia coli RecBCD helicase-nuclease promotes vital homologous recombination-based repair of DNA double-strand breaks. The RecB nuclease domain (Nuc) is connected to the RecB helicase domain by a 19-amino-acid tether. When...
4.
Amundsen S, Taylor A, Smith G
Sci Rep
. 2020 Nov;
10(1):19415.
PMID: 33154402
Repair of broken DNA by homologous recombination requires coordinated enzymatic reactions to prepare it for interaction with intact DNA. The multiple activities of enterobacterial RecBCD helicase-nuclease are coordinated by Chi...
5.
Amundsen S, Smith G
Nucleic Acids Res
. 2018 Nov;
47(1):197-209.
PMID: 30445486
In bacteria, repair of DNA double-strand breaks uses a highly conserved helicase-nuclease complex to unwind DNA from a broken end and cut it at specific DNA sequences called Chi. In...
6.
Amundsen S, Sharp J, Smith G
Genetics
. 2016 Jul;
204(1):139-52.
PMID: 27401752
RecBCD enzyme is a complex, three-subunit protein machine essential for the major pathway of DNA double-strand break repair and homologous recombination in Escherichia coli Upon encountering a Chi recombination-hotspot during...
7.
Taylor A, Amundsen S, Smith G
Nucleic Acids Res
. 2016 Jun;
44(17):8216-28.
PMID: 27330137
Homologous recombination occurs especially frequently near special chromosomal sites called hotspots. In Escherichia coli, Chi hotspots control RecBCD enzyme, a protein machine essential for the major pathway of DNA break-repair...
8.
Taylor A, Amundsen S, Guttman M, Lee K, Luo J, Ranish J, et al.
J Mol Biol
. 2014 Jul;
426(21):3479-99.
PMID: 25073102
Faithful repair of DNA double-strand breaks by homologous recombination is crucial to maintain functional genomes. The major Escherichia coli pathway of DNA break repair requires RecBCD enzyme, a complex protein...
9.
Amundsen S, Spicer T, Karabulut A, Londono L, Eberhart C, Fernandez Vega V, et al.
ACS Chem Biol
. 2012 Mar;
7(5):879-91.
PMID: 22443934
The AddAB and RecBCD helicase-nucleases are related enzymes prevalent among bacteria but not eukaryotes and are instrumental in the repair of DNA double-strand breaks and in genetic recombination. Although these...
10.
Amundsen S, Fero J, Salama N, Smith G
J Biol Chem
. 2009 Apr;
284(25):16759-16766.
PMID: 19395381
Helicobacter pylori infection of the human stomach is associated with disease-causing inflammation that elicits DNA damage in both bacterial and host cells. Bacteria must repair their DNA to persist. The...