Susan C Hubchak
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Explore the profile of Susan C Hubchak including associated specialties, affiliations and a list of published articles.
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11
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375
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Recent Articles
1.
Liu X, Taylor S, Gromer K, Zhang D, Hubchak S, LeCuyer B, et al.
PLoS One
. 2022 Jan;
17(1):e0261789.
PMID: 35030194
Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of liver diseases in the United States and can progress to cirrhosis, end-stage liver disease and need for...
2.
Liu X, Guo G, Kong B, Hilburn D, Hubchak S, Park S, et al.
Hepatology
. 2018 Jan;
68(1):304-316.
PMID: 29377207
Conclusion: FXR signaling activates the IRE1α/XBP1 pathway in vivo and in vitro. FXR pathway activation increases XBP1 splicing and enhances p-IRE1α expression. These effects are mediated, at least in part,...
3.
Liu X, Henkel A, LeCuyer B, Hubchak S, Schipma M, Zhang E, et al.
J Lipid Res
. 2017 Jan;
58(3):504-511.
PMID: 28039331
The unfolded protein response (UPR) is an adaptive response to endoplasmic reticulum stress and the inositol-requiring enzyme 1α/X-box binding protein 1 (IRE1α/XBP1) pathway of the UPR is important in lipid...
4.
Liu X, Hubchak S, Browne J, Schnaper H
Cell Signal
. 2014 Jun;
26(10):2276-83.
PMID: 24905473
Transforming growth factor-β (TGF-β) signaling plays an important and complex role in renal fibrogenesis. The seemingly simple TGF-β/Smad cascade is intensively regulated at several levels, including crosstalk with other signaling...
5.
Hypoxia-inducible factor-2α and TGF-β signaling interact to promote normoxic glomerular fibrogenesis
Hanna C, Hubchak S, Liang X, Rozen-Zvi B, Schumacker P, Hayashida T, et al.
Am J Physiol Renal Physiol
. 2013 Aug;
305(9):F1323-31.
PMID: 23946285
Hypoxia-inducible factors (HIFs) are transcription factors consisting of an oxygen-sensitive α-subunit binding to a stable β-subunit. HIFs regulate multiple signaling pathways that could contribute to fibrogenesis, supporting their potential role...
6.
Rozen-Zvi B, Hayashida T, Hubchak S, Hanna C, Platanias L, Schnaper H
Am J Physiol Renal Physiol
. 2013 Jun;
305(4):F485-94.
PMID: 23761672
Transforming growth factor (TGF)-β is a major mediator of kidney fibrosis. In the past decade it was recognized that, besides canonical Smad signaling, many other signaling pathways participate in the...
7.
Schnaper H, Hubchak S, Runyan C, Browne J, Finer G, Liu X, et al.
Pediatr Nephrol
. 2010 Mar;
25(11):2223-30.
PMID: 20352456
The data regarding the pathogenesis of progressive kidney disease implicate cytokine effects, physiological factors, and myriad examples of relatively nonspecific cellular dysfunction. The sheer volume of information being generated on...
8.
Hubchak S, Sparks E, Hayashida T, Schnaper H
Am J Physiol Renal Physiol
. 2009 Sep;
297(5):F1316-23.
PMID: 19726546
Transforming growth factor (TGF)-beta is a central mediator in the progression of glomerulosclerosis, leading to accumulation of aberrant extracellular matrix proteins and inappropriate expression of smooth muscle alpha-actin in the...
9.
Schnaper H, Jandeska S, Runyan C, Hubchak S, Basu R, Curley J, et al.
Front Biosci (Landmark Ed)
. 2009 Mar;
14(7):2448-65.
PMID: 19273211
Transforming growth factor (TGF)-beta is a central stimulus of the events leading to chronic progressive kidney disease, having been implicated in the regulation of cell proliferation, hypertrophy, apoptosis and fibrogenesis....
10.
Hubchak S, Runyan C, Kreisberg J, Schnaper H
J Am Soc Nephrol
. 2003 Jul;
14(8):1969-80.
PMID: 12874450
TGF-beta1 has been implicated in glomerular extracellular matrix accumulation, although the precise cellular mechanism(s) by which this occurs is not fully understood. The authors have previously shown that the Smad...