Suresh Velnati
Overview
Explore the profile of Suresh Velnati including associated specialties, affiliations and a list of published articles.
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5
Citations
42
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Recent Articles
1.
Velnati S, Centonze S, Rossino G, Purghe B, Antona A, Racca L, et al.
Front Immunol
. 2023 May;
14:1043603.
PMID: 37138877
Background: Phosphorylation of diacylglycerol by diacylglycerol-kinases represents a major inhibitory event constraining T cell activation upon antigen engagement. Efficient TCR signalling requires the inhibition of the alpha isoform of diacylglycerol...
2.
Velnati S, Centonze S, Girivetto F, Baldanzi G
Int J Mol Sci
. 2021 Jun;
22(11).
PMID: 34072296
Diacylglycerol kinases are intracellular enzymes that control the balance between the secondary messengers diacylglycerol and phosphatidic acid. DGKα and DGKζ are the prominent isoforms that restrain the intensity of T...
3.
Velnati S, Centonze S, Girivetto F, Capello D, Biondi R, Bertoni A, et al.
Biomedicines
. 2021 Jan;
9(1).
PMID: 33419210
PKCζ and PKCι/λ form the atypical protein kinase C subgroup, characterised by a lack of regulation by calcium and the neutral lipid diacylglycerol. To better understand the regulation of these...
4.
Velnati S, Massarotti A, Antona A, Talmon M, Fresu L, Galetto A, et al.
J Enzyme Inhib Med Chem
. 2019 Nov;
35(1):96-108.
PMID: 31690133
A series of analogues of Amb639752, a novel diacylglycerol kinase (DGK) inhibitor recently discovered by us via virtual screening, have been tested. The compounds were evaluated as DGK inhibitors on...
5.
Velnati S, Ruffo E, Massarotti A, Talmon M, Varma K, Gesu A, et al.
Eur J Med Chem
. 2019 Jan;
164:378-390.
PMID: 30611057
As part of an effort to identify druggable diacylglycerol kinase alpha (DGKα) inhibitors, we used an in-silico approach based on chemical homology with the two commercially available DGKα inhibitors R59022...