» Authors » Sunyia Hussain

Sunyia Hussain

Explore the profile of Sunyia Hussain including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 14
Citations 195
Followers 0
Related Specialties
Top 10 Co-Authors
Published In
Affiliations
Soon will be listed here.
Recent Articles
1.
Han C, Nguyen K, Berkow M, Hussain S, Kiani A, Kinnebrew M, et al.
Biophys J . 2022 Nov; 122(1):168-179. PMID: 36352784
The functional properties of proteorhodopsin (PR) have been found to be strongly modulated by oligomeric distributions and lipid membrane mimetics. This study aims to distinguish and explain their effects by...
2.
Hussain S, Peterson J, Bernstein H
mBio . 2021 Aug; 12(4):e0169621. PMID: 34399610
Many integral membrane proteins form oligomeric complexes, but the assembly of these structures is poorly understood. Here, we show that the assembly of OmpC, a trimeric porin that resides in...
3.
Gulezian E, Crivello C, Bednenko J, Zafra C, Zhang Y, Colussi P, et al.
Trends Pharmacol Sci . 2021 Jul; 42(8):657-674. PMID: 34270922
Integral membrane proteins (MPs) are important drug targets across most fields of medicine, but historically have posed a major challenge for drug discovery due to difficulties in producing them in...
4.
Bednenko J, Colussi P, Hussain S, Zhang Y, Clark T
Handb Exp Pharmacol . 2021 May; 267:507-545. PMID: 33963460
Monoclonal antibodies combine specificity and high affinity binding with excellent pharmacokinetic properties and are rapidly being developed for a wide range of drug targets including clinically important potassium ion channels....
5.
Hussain S, Peterson J, Bernstein H
Sci Rep . 2020 Mar; 10(1):4557. PMID: 32165713
Bacterial outer membrane proteins (OMPs) contain a unique "β barrel" segment that is inserted into the membrane by the barrel assembly machinery (Bam) complex by an unknown mechanism. OMP assembly...
6.
Yan Z, Hussain S, Wang X, Bernstein H, Bardwell J
Mol Microbiol . 2019 Aug; 112(5):1373-1387. PMID: 31369167
OsmY is a widely conserved but poorly understood 20 kDa periplasmic protein. Using a folding biosensor, we previously obtained evidence that OsmY has molecular chaperone activity. To discover natural OsmY...
7.
Peterson J, Hussain S, Bernstein H
Mol Microbiol . 2018 Aug; 110(1):143-159. PMID: 30107065
Although the barrel assembly machinery (Bam) complex has been shown to facilitate the insertion of β barrel proteins into the bacterial outer membrane (OM), the stage at which β barrels...
8.
Jahnke J, Idso M, Hussain S, Junk M, Fisher J, Phan D, et al.
J Am Chem Soc . 2018 Mar; 140(11):3892-3906. PMID: 29533066
A versatile synthetic protocol is reported that allows high concentrations of functionally active membrane proteins to be incorporated in mesostructured silica materials. Judicious selections of solvent, surfactant, silica precursor species,...
9.
Hussain S, Bernstein H
J Biol Chem . 2018 Jan; 293(8):2959-2973. PMID: 29311257
Most proteins that reside in the bacterial outer membrane (OM) have a distinctive "β-barrel" architecture, but the assembly of these proteins is poorly understood. The spontaneous assembly of OM proteins...
10.
Lalli D, Idso M, Andreas L, Hussain S, Baxter N, Han S, et al.
J Am Chem Soc . 2017 Jul; 139(37):13006-13012. PMID: 28724288
The structures and properties of membrane proteins in lipid bilayers are expected to closely resemble those in native cell-membrane environments, although they have been difficult to elucidate. By performing solid-state...