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Sungyun Cho

Explore the profile of Sungyun Cho including associated specialties, affiliations and a list of published articles. Areas
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Articles 16
Citations 417
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Recent Articles
1.
Kim J, Cho S, Jeong M, Rivera-Piza A, Kim Y, Wu C, et al.
Phytomedicine . 2025 Mar; 140:156599. PMID: 40088737
Background: Olfactory receptors (ORs) are present in non-olfactory tissues and contribute to diverse biological roles beyond smell perception. Among them, OR51E2 has been associated with cancer biology, and its activator,...
2.
Koundouros N, Nagiec M, Bullen N, Noch E, Burgos-Barragan G, Li Z, et al.
Science . 2025 Mar; 387(6739):eadm9805. PMID: 40080571
Diet influences macronutrient availability to cells, and although mechanisms of sensing dietary glucose and amino acids are well characterized, less is known about sensing lipids. We defined a nutrient signaling...
3.
Xu K, Wang Y, Wang F, Guo Y, Ren Y, Low V, et al.
J Cachexia Sarcopenia Muscle . 2025 Feb; 16(1):e13734. PMID: 39971710
Background: Cachexia is a wasting syndrome associated with imbalanced energy metabolism and loss of adipose and muscle tissues and contributes to morbidity and mortality in ageing as well as in...
4.
He L, Cho S, Blenis J
Genes Dev . 2024 Nov; 39(1-2):109-131. PMID: 39572234
The mechanistic target of rapamycin (mTOR) pathway senses and integrates various environmental and intracellular cues to regulate cell growth and proliferation. As a key conductor of the balance between anabolic...
5.
Ogawa T, Isik M, Wu Z, Kurmi K, Meng J, Cho S, et al.
Mol Cell . 2024 Nov; 84(23):4558-4575.e8. PMID: 39571580
Cellular growth and organismal development are remarkably complex processes that require the nutrient-responsive kinase mechanistic target of rapamycin complex 1 (mTORC1). Anticipating that important mTORC1 functions remained to be identified,...
6.
Cho S, Chun Y, He L, Ramirez C, Ganesh K, Jeong K, et al.
Mol Cell . 2023 Aug; 83(16):3010-3026.e8. PMID: 37595559
The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that stimulates macromolecule synthesis through transcription, RNA processing, and post-translational modification of metabolic enzymes. However,...
7.
Xu K, Guo Y, Wang Y, Ren Y, Low V, Cho S, et al.
Aging Cell . 2022 Dec; 22(2):e13760. PMID: 36567449
Aging-associated microbial dysbiosis exacerbates various disorders and dysfunctions, and is a major contributor to morbidity and mortality in the elderly, but the underlying cause of this aging-related syndrome is confusing....
8.
Li Z, Low V, Luga V, Sun J, Earlie E, Parang B, et al.
Nat Commun . 2022 Oct; 13(1):6239. PMID: 36266345
The systemic metabolic shifts that occur during aging and the local metabolic alterations of a tumor, its stroma and their communication cooperate to establish a unique tumor microenvironment (TME) fostering...
9.
He L, Endress J, Cho S, Li Z, Zheng Y, Asara J, et al.
Sci Adv . 2022 May; 8(20):eabm8786. PMID: 35594343
Serine/one-carbon metabolism provides critical resources for nucleotide biosynthesis and epigenetic maintenance and is thus necessary in cancer cell growth, although the detailed regulatory mechanisms remain unclear. We uncover a critical...
10.
Cho S, Lee G, Pickering B, Jang C, Park J, He L, et al.
Mol Cell . 2021 Mar; 81(10):2064-2075.e8. PMID: 33756105
Dysregulated mTORC1 signaling alters a wide range of cellular processes, contributing to metabolic disorders and cancer. Defining the molecular details of downstream effectors is thus critical for uncovering selective therapeutic...