Sumei Ren
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Explore the profile of Sumei Ren including associated specialties, affiliations and a list of published articles.
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44
Citations
230
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Recent Articles
1.
Maity R, Dungan O, Perras F, Li J, Liu D, Ren S, et al.
J Am Chem Soc
. 2024 Nov;
146(49):34141-34151.
PMID: 39579128
Isotopic labeling is a powerful technique extensively used in the pharmaceutical industry. By tracking isotope-labeled molecules, researchers gain unique and invaluable insights into the pharmacokinetics and pharmacodynamics of new drug...
2.
Li J, Lin Q, Dungan O, Fu Y, Ren S, Ruccolo S, et al.
J Am Chem Soc
. 2024 Nov;
146(46):31497-31506.
PMID: 39514417
Hydrogen isotopically labeled compounds have extensive utility across diverse domains, especially in drug discovery and development. However, synthesis of the labeled compounds with exclusive site selectivity and/or high isotope incorporation...
3.
Weng W, Ren S, Teng C, Guo J, Guo Q, Zhang W, et al.
Bioorg Med Chem
. 2024 Feb;
100:117615.
PMID: 38342079
sTF (sialyl-Thomsen-Friedenreich) is a type of tumor-associated carbohydrate antigens (TACAs) and is highly expressed in various human malignancies. To validate if sTF could be a valuable molecular target for future...
4.
Anderson M, Dockendorf M, McIntosh I, Xie I, Breidinger S, Meng D, et al.
AAPS J
. 2022 Apr;
24(3):52.
PMID: 35384529
In-clinic dried blood spot (DBS) pharmacokinetic (PK) sampling was incorporated into two phase 3 studies of verubecestat for Alzheimer's disease (EPOCH [NCT01739348] and APECS [NCT01953601]), as a potential alternative to...
5.
Yang H, Huang Z, Lehnherr D, Lam Y, Ren S, Strotman N
J Am Chem Soc
. 2022 Mar;
144(11):5010-5022.
PMID: 35263094
Employment of a combination of an organophotoredox catalyst with Wilkinson's catalyst (Rh(PPh)Cl) has given rise to an unprecedented method for hydrogen-isotope exchange (HIE) of aliphatic C(sp)-H bonds of complex pharmaceuticals...
6.
Wang P, Wang J, Yin W, Wang X, Song N, Ren S, et al.
Org Lett
. 2022 Jan;
24(3):971-976.
PMID: 35045255
Gold(I)-catalyzed stereoselective β-glycosylation of primary alcohols is achieved using the orthogonally protected mannosyl α--hexynylbenzoate (OABz) donors devoid of 4,6--tethering groups used in conventionally constructing β-mannosidic bonds. The potential of this...
7.
Li W, Wang Y, Lohith T, Zeng Z, Tong L, Mazzola R, et al.
Sci Transl Med
. 2022 Jan;
14(627):eabg3684.
PMID: 35020407
Positron emission tomography (PET) ligands play an important role in the development of therapeutics by serving as target engagement or pharmacodynamic biomarkers. Here, we describe the discovery and translation of...
8.
Ren S, Wang X, Jin G
Int J Biol Sci
. 2022 Jan;
18(1):166-179.
PMID: 34975325
The use of large molecules for immunotherapy has led to exciting developments in cancer treatment, such as the development of PD-1/PD-L1 antibodies. However, small molecule targeted therapies still lack effective...
9.
Ren S, Wang X, Song J, Jin G
Bioorg Chem
. 2021 Oct;
117:105419.
PMID: 34689082
A series of novel ibrutinib analogues was synthesized, and their proliferation inhibitory activities against various B lymphoma cell lines (DaudiB and Raji) and solid tumor cells (B16, CT26, HepG2 and...
10.
Ren S, Zhang M, Wang Y, Guo J, Wang J, Li Y, et al.
Bioorg Med Chem
. 2021 May;
41:116224.
PMID: 34058663
Cabazitaxel is one of the most recently FDA-approved taxane anticancer agent. In view of the advantages in preclinical and clinical data of cabazitaxel over former toxoids, the synthesis and biological...