Sujay P Sau
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Explore the profile of Sujay P Sau including associated specialties, affiliations and a list of published articles.
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16
Citations
229
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Recent Articles
1.
Chim N, Shi C, Sau S, Nikoomanzar A, Chaput J
Nat Commun
. 2017 Nov;
8(1):1810.
PMID: 29180809
Darwinian evolution experiments carried out on xeno-nucleic acid (XNA) polymers require engineered polymerases that can faithfully and efficiently copy genetic information back and forth between DNA and XNA. However, current...
2.
Sau S, Chaput J
Org Lett
. 2017 Aug;
19(16):4379-4382.
PMID: 28766949
α-l-Threofuranosyl nucleoside 3'-triphosphates (tNTPs) bearing the four genetic bases adenine (A), cytosine (C), guanine (G), and thymine (T) were synthesized on a gram scale using an iterative phosphorylation strategy that...
3.
Sau S, Chaput J
Bioorg Med Chem Lett
. 2016 Jun;
26(14):3271-3273.
PMID: 27246616
TNA (α-l-threofuranosyl nucleoside) triphosphates of adenosine (tATP), guanosine (tGTP), cytidine (tCTP), and thymidine (tTTP) were synthesized from their corresponding 3'-O-phosphoramidite derivatives using a novel one-pot reaction that is less moisture...
4.
Culbertson M, Temburnikar K, Sau S, Liao J, Bala S, Chaput J
Bioorg Med Chem Lett
. 2016 Apr;
26(10):2418-2421.
PMID: 27080186
Chemically modified oligonucleotides are routinely used as diagnostic and therapeutic agents due to their enhanced biological stability relative to natural DNA and RNA. Here, we examine the biological stability of...
5.
Larsen A, Dunn M, Hatch A, Sau S, Youngbull C, Chaput J
Nat Commun
. 2016 Apr;
7:11235.
PMID: 27044725
Polymerases that synthesize artificial genetic polymers hold great promise for advancing future applications in synthetic biology. However, engineering natural polymerases to replicate unnatural genetic polymers is a challenging problem. Here...
6.
Sau S, Fahmi N, Liao J, Bala S, Chaput J
J Org Chem
. 2016 Feb;
81(6):2302-7.
PMID: 26895480
Recent advances in polymerase engineering have made it possible to copy information back and forth between DNA and artificial genetic polymers composed of TNA (α-L-threofuranosyl-(3',2') nucleic acid). This property, coupled...
7.
Sau S, Larsen A, Chaput J
Bioorg Med Chem Lett
. 2014 Dec;
24(24):5692-5694.
PMID: 25467163
Affinity purification of poly-adenylated biomolecules using solid supports that are derivatized with poly-thymidine oligonucleotides provides a powerful method for isolating cellular mRNA. These systems have also been used to purify...
8.
Larsen A, Gillig A, Shah P, Sau S, Fenton K, Chaput J
Anal Chem
. 2014 Jun;
86(15):7219-23.
PMID: 24970615
In vitro selection technologies are important tools for identifying high affinity peptides to proteins of broad medical and biological interest. However, the technological advances that have made it possible to...
9.
Didion B, Karmakar S, Guenther D, Sau S, Verstegen J, Hrdlicka P
Chembiochem
. 2013 Sep;
14(13):1534-1538.
PMID: 24038876
The invasion has begun: Invaders are shown to recognize DNA hairpins in cell-free assays and chromosomal DNA during non-denaturing fluorescence in situ hybridization (nd-FISH) experiments. As Invaders are devoid of...
10.
Sau S, Madsen A, Podbevsek P, Andersen N, Kumar T, Andersen S, et al.
J Org Chem
. 2013 Sep;
78(19):9560-70.
PMID: 24032477
The development of synthetic agents that recognize double-stranded DNA (dsDNA) is a long-standing goal that is inspired by the promise for tools that detect, regulate, and modify genes. Progress has...