Sue-Jie Koo
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Explore the profile of Sue-Jie Koo including associated specialties, affiliations and a list of published articles.
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9
Citations
276
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Recent Articles
1.
Koo S, Garg N
Redox Biol
. 2019 May;
24:101198.
PMID: 31048245
Macrophages (Mφ) are central players in mediating proinflammatory and immunomodulatory functions. Unchecked Mφ activities contribute to pathology across many diseases, including those caused by infectious pathogens and metabolic disorders. A...
2.
Zago M, Wiktorowicz J, Spratt H, Koo S, Barrientos N, Nunez Burgos A, et al.
Front Microbiol
. 2019 Jan;
9:3320.
PMID: 30697201
infection causes Chagas disease (ChD) presented by dilated cardiomyopathy and heart failure. During infection, oxidative and nitrosative stresses are elicited by the immune cells for control the pathogen; however, excess...
3.
Koo S, Szczesny B, Wan X, Putluri N, Garg N
Front Immunol
. 2018 Mar;
9:202.
PMID: 29503646
Metabolism provides substrates for reactive oxygen species (ROS) and nitric oxide (NO) generation, which are a part of the macrophage (Mφ) anti-microbial response. Mφs infected with () produce insufficient levels...
4.
Chowdhury I, Koo S, Gupta S, Liang L, Bahar B, Silla L, et al.
J Innate Immun
. 2016 Dec;
9(2):203-216.
PMID: 27902980
Background: Chronic inflammation and oxidative stress are hallmarks of chagasic cardiomyopathy (CCM). In this study, we determined if microparticles (MPs) generated during Trypanosoma cruzi (Tc) infection carry the host's signature...
5.
Wan X, Wen J, Koo S, Liang L, Garg N
PLoS Pathog
. 2016 Oct;
12(10):e1005954.
PMID: 27764247
Chronic chagasic cardiomyopathy (CCM) is presented by increased oxidative/inflammatory stress and decreased mitochondrial bioenergetics. SIRT1 senses the redox changes and integrates mitochondrial metabolism and inflammation; and SIRT1 deficiency may be...
6.
Koo S, Chowdhury I, Szczesny B, Wan X, Garg N
Infect Immun
. 2016 Oct;
84(12):3527-3541.
PMID: 27698021
Trypanosoma cruzi is the causative agent of chronic chagasic cardiomyopathy. Why macrophages (mφs), the early responders to infection, fail to achieve parasite clearance is not known. Mouse (RAW 264.7) and...
7.
Koo S, Spratt H, Soman K, Stafford S, Gupta S, Petersen J, et al.
Int J Proteomics
. 2016 Sep;
2016:1384523.
PMID: 27635260
Nitric oxide (NO) protects the heart against ischemic injury; however, NO- and superoxide-dependent S-nitrosylation (S-NO) of cysteines can affect function of target proteins and play a role in disease outcome....
8.
Zago M, Hosakote Y, Koo S, Dhiman M, Pineyro M, Parodi-Talice A, et al.
Infect Immun
. 2016 Apr;
84(6):1842-1856.
PMID: 27068090
Trypanosoma cruzi species is categorized into six discrete typing units (TcI to TcVI) of which TcI is most abundantly noted in the sylvatic transmission cycle and considered the major cause...
9.
Garg N, Soman K, Zago M, Koo S, Spratt H, Stafford S, et al.
PLoS Negl Trop Dis
. 2016 Feb;
10(2):e0004490.
PMID: 26919708
Trypanosoma cruzi (Tc) infection causes chagasic cardiomyopathy; however, why 30-40% of the patients develop clinical disease is not known. To discover the pathomechanisms in disease progression, we obtained the proteome...