Sudhakar Kalakonda
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Explore the profile of Sudhakar Kalakonda including associated specialties, affiliations and a list of published articles.
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16
Citations
272
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Recent Articles
1.
Yu T, Kalakonda S, Liu X, Han N, Chung H, Xiao L, et al.
JCI Insight
. 2022 Oct;
7(19).
PMID: 36214222
Intestinal epithelial integrity is commonly disrupted in patients with critical disorders, but the exact underlying mechanisms are unclear. Long noncoding RNAs transcribed from ultraconserved regions (T-UCRs) control different cell functions...
2.
Astrocyte-derived microparticles initiate a neuroinflammatory cycle due to carbon monoxide poisoning
Ruhela D, Bhopale V, Kalakonda S, Thom S
Brain Behav Immun Health
. 2021 Dec;
18:100398.
PMID: 34917988
We hypothesized that carbon monoxide (CO) establishes an inflammatory cycle mediated by microparticles (MPs). Mice exposed to a CO protocol (1000 ppm for 40 min and then 3000 ppm for...
3.
Li G, Makar T, Gerzanich V, Kalakonda S, Ivanova S, Pereira E, et al.
mBio
. 2020 Dec;
11(6).
PMID: 33293383
Successful treatment of HIV-infected patients with combinational antiretroviral therapies (cART) can now prolong patients' lives to nearly normal life spans. However, the new challenge faced by many of those HIV-infected...
4.
Xiao L, Li X, Chung H, Kalakonda S, Cai J, Cao S, et al.
Gastroenterology
. 2019 May;
157(3):731-743.
PMID: 31103627
Background & Aims: Paneth cells secrete antimicrobial proteins including lysozyme via secretory autophagy as part of the mucosal protective response. The ELAV like RNA-binding protein 1 (ELAVL1, also called HuR)...
5.
Xiao L, Wu J, Wang J, Chung H, Kalakonda S, Rao J, et al.
Gastroenterology
. 2017 Oct;
154(3):599-611.
PMID: 29042220
Background And Aims: The mammalian intestinal epithelium self-renews rapidly and homeostasis is preserved via tightly controlled mechanisms. Long noncoding RNAs transcribed from ultraconserved regions (T-UCRs) control different cell functions, but...
6.
Kalakonda S, Nallar S, Jaber S, Keay S, Rorke E, Munivenkatappa R, et al.
Proc Natl Acad Sci U S A
. 2013 Oct;
110(45):E4213-22.
PMID: 24145455
Gene-associated with retinoid-interferon induced mortality-19 (GRIM-19), a STAT3-inhibitory protein, was isolated as a growth-suppressive gene product using a genome-wide expression knockdown screen. We and others have shown a loss of...
7.
Nallar S, Kalakonda S, Lindner D, Lorenz R, Lamarre E, Weihua X, et al.
J Biol Chem
. 2013 Feb;
288(11):7930-7941.
PMID: 23386605
The signal transducer and activator of transcription 3 (STAT3) protein is critical for multiple cytokine and growth factor-induced biological responses in vivo. Its transcriptional activity is controlled by a transient...
8.
Nallar S, Kalakonda S, Sun P, Kalvakolanu D
Transl Oncogenomics
. 2011 May;
3:67-79.
PMID: 21566745
Gene associated with retinoid-interferon-β-induced mortality (GRIM)-19, was originally identified as a critical regulatory protein necessary for Interferon-β-Retinoic acid-induced cell death. Overexpression of GRIM-19 activates cell death and its suppression or...
9.
Nallar S, Kalakonda S, Sun P, Ohmori Y, Hiroi M, Mori K, et al.
Am J Pathol
. 2010 Jul;
177(2):896-907.
PMID: 20595633
We have previously isolated GRIM-19, a novel growth suppressor, using a genetic method. GRIM-19 ablates cell growth by inhibiting the transcription factor signal transducer and activator of transcription 3 (STAT3)....
10.
Sun P, Nallar S, Raha A, Kalakonda S, Velalar C, Reddy S, et al.
J Biol Chem
. 2010 Jun;
285(36):27545-52.
PMID: 20522552
GRIM-19 (Gene associated with Retinoid-IFN-induced Mortality-19) was originally isolated as a growth suppressor in a genome-wide knockdown screen with antisense libraries. Like classical tumor suppressors, mutations, and/or loss of GRIM-19...