Sudha R Somarajan
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Explore the profile of Sudha R Somarajan including associated specialties, affiliations and a list of published articles.
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10
Citations
234
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Recent Articles
1.
Montealegre M, Singh K, Somarajan S, Yadav P, Chang C, Spencer R, et al.
Infect Immun
. 2016 Mar;
84(5):1491-1500.
PMID: 26930703
Enterococcus faecium is an important cause of hospital-associated infections, including urinary tract infections (UTIs), bacteremia, and infective endocarditis. Pili have been shown to play a role in the pathogenesis of...
2.
Somarajan S, La Rosa S, Singh K, Roh J, Hook M, Murray B
Infect Immun
. 2015 Sep;
83(12):4653-61.
PMID: 26371130
The interaction between bacteria and fibronectin is believed to play an important role in the pathogenicity of clinically important Gram-positive cocci. In the present study, we identified a gene encoding...
3.
Singh K, La Rosa S, Somarajan S, Roh J, Murray B
Infect Immun
. 2015 Sep;
83(12):4487-94.
PMID: 26351286
EfbA is a PavA-like fibronectin adhesin of Enterococcus faecalis previously shown to be important in experimental urinary tract infection. Here, we expressed and purified the E. faecalis OG1RF EfbA and...
4.
Becker A, Kannan T, Taylor A, Pakhomova O, Zhang Y, Somarajan S, et al.
Proc Natl Acad Sci U S A
. 2015 Apr;
112(16):5165-70.
PMID: 25848012
Mycoplasma pneumoniae (Mp) infections cause tracheobronchitis and "walking" pneumonia, and are linked to asthma and other reactive airway diseases. As part of the infectious process, the bacterium expresses a 591-aa...
5.
Bose S, Segovia J, Somarajan S, Chang T, Kannan T, Baseman J
mBio
. 2014 Dec;
5(6).
PMID: 25538194
Unlabelled: The inflammasome is a major regulator of inflammation through its activation of procaspase-1, which cleaves prointerleukin-1β (pro-IL-1β) into its mature form. IL-1β is a critical proinflammatory cytokine that dictates...
6.
Somarajan S, Al-Asadi F, Ramasamy K, Pandranki L, Baseman J, Kannan T
mBio
. 2014 Aug;
5(4).
PMID: 25139904
Unlabelled: Mycoplasma pneumoniae synthesizes a novel human surfactant protein A (SP-A)-binding cytotoxin, designated community-acquired respiratory distress syndrome (CARDS) toxin, that exhibits ADP-ribosylating and vacuolating activities in mammalian cells and is...
7.
Somarajan S, Roh J, Singh K, Weinstock G, Murray B
Infect Immun
. 2014 Jun;
82(9):3580-7.
PMID: 24914215
The collagen adhesin Acm was the first virulence determinant reported to be important for the pathogenesis of Enterococcus faecium in a rat infective endocarditis model. We had previously reported that...
8.
Almohamad S, Somarajan S, Singh K, Nallapareddy S, Murray B
FEMS Microbiol Lett
. 2014 Mar;
353(2):151-6.
PMID: 24606170
Enterococcus faecium, a major cause of nosocomial infections, is often isolated from conditions where biofilm is considered to be important in the establishment of infections. We investigated biofilm formation among...
9.
Somarajan S, Murray B
J Infect Dis
. 2013 Mar;
207(11):1633-6.
PMID: 23447697
No abstract available.
10.
Somarajan S, Kannan T, Baseman J
Cell Microbiol
. 2010 Aug;
12(12):1821-31.
PMID: 20690923
We identified Mpn133 as a Ca(2+)-dependent cytotoxic nuclease of Mycoplasma pneumoniae. Flow cytometry analysis and immunofluorescence studies revealed the binding and internalization of recombinant Mpn133 (rMpn133) in human airway A549...