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Magnus Hook

Explore the profile of Magnus Hook including associated specialties, affiliations and a list of published articles. Areas
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Articles 129
Citations 5680
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Recent Articles
1.
Gomez A, Kjerfve C, Choi M, Liu W, Churion K, Thomas S, et al.
mBio . 2024 Nov; 15(12):e0190724. PMID: 39560391
Importance: This study uncovers a new virulence mechanism in ST2 bloodstream isolates. We identify a mobile genetic element (MGE) characteristic of an integrated conjugated element (ICE). pICE-Sepi-ST2 carries the genetic...
2.
Hu Y, Sarkar A, Song K, Michael S, Hook M, Wang R, et al.
Cell Rep Med . 2024 Apr; 5(5):101530. PMID: 38688275
Chimeric antigen receptor (CAR) T cell therapy is hindered in solid tumor treatment due to the immunosuppressive tumor microenvironment and suboptimal T cell persistence. Current strategies do not address nutrient...
3.
Zheng C, Wei Y, Zhang P, Lin K, He D, Teng H, et al.
Nat Struct Mol Biol . 2023 Nov; 30(12):1878-1892. PMID: 37932451
Emerging evidence suggests that cryptic translation beyond the annotated translatome produces proteins with developmental or physiological functions. However, functions of cryptic non-canonical open reading frames (ORFs) in cancer remain largely...
4.
Bertoglio F, Ko Y, Thomas S, Giordano L, Scommegna F, Meier D, et al.
Front Immunol . 2023 Oct; 14:1221108. PMID: 37828992
pathology is caused by a plethora of virulence factors able to combat multiple host defence mechanisms. Fibrinogen (Fg), a critical component in the host coagulation cascade, plays an important role...
5.
Zeng Y, Woolley M, Chockalingam K, Thomas B, Arora S, Hook M, et al.
Nucleic Acids Res . 2023 Aug; 51(16):e89. PMID: 37548398
We describe a novel method for in vitro protein display-click display-that does not depend on maintaining RNA integrity during biopanning and yields covalently linked protein-cDNA complexes from double-stranded input DNA...
6.
Pagba C, Gupta A, Naji A, van der Hoeven D, Churion K, Liang X, et al.
ACS Bio Med Chem Au . 2023 Apr; 2(6):617-626. PMID: 37101428
We describe a small molecule ligand (2-hydroxy-5-{[(2-phenylcyclopropyl) carbonyl] amino} benzoic acid) as an initial lead for the development of direct inhibitors of KRAS, a notoriously difficult anticancer drug target. We...
7.
Picker J, Lan Z, Arora S, Green M, Hahn M, Cosgriff-Hernandez E, et al.
Front Bioeng Biotechnol . 2022 Apr; 10:840939. PMID: 35372322
Collagens are the major structural component in animal extracellular matrices and are critical signaling molecules in various cell-matrix interactions. Its unique triple helical structure is enabled by tripeptide Gly-X-Y repeats....
8.
Borza C, Bolas G, Zhang X, Monroe M, Zhang M, Meiler J, et al.
Front Cell Dev Biol . 2022 Mar; 10:836797. PMID: 35309920
Integrins and discoidin domain receptors (DDRs) 1 and 2 promote cell adhesion and migration on both fibrillar and non fibrillar collagens. Collagen I contains DDR and integrin selective binding motifs;...
9.
Thomas S, Arora S, Liu W, Churion K, Wu Y, Hook M
mBio . 2021 Aug; 12(4):e0116721. PMID: 34340548
Staphylococcus aureus can target a variety of tissues, causing life-threatening infections. The basis for this diversity stems from the microorganism's ability to spread in the vascular system throughout the body....
10.
Hook M, Foster T
Front Microbiol . 2021 Jun; 12:681880. PMID: 34093507
No abstract available.